Solvation of platinum anti-cancer drugs in methanol-water mixtures.

Solubilities and transfer chemical potentials of carboplatin, cisplatin, iproplatin, and several related platinum complexes have been determined in methanol-water mixtures. The range of solvation behaviour is discussed in relation to possible oral administration of complexes of this type.

Solubilities and solvation of aluminum(III), iron(III), and indium(III) 8-hydroxyquinolinates in methanol/water mixtures.

Solubilities are reported for aluminum, indium, and iron(III) complexes of 8-hydroxyquinoline and its 5-nitro, 5-sulfonato, and 7-iodo-5-sulfonato derivatives in water, methanol, and water/methanol mixtures, at 298.2 K. Transfer chemical potentials for the respective complexes have been derived from these data, and their trends are discussed in terms of solvation of the complexes by water and methanol.