[Report of experiences with high dosage Hydiphen infusion treatment of depressive syndromes]. / Erfahrungsbericht über hochdosierte Hydiphen-Infusionsbehandlung bei depressiven Syndromen.

25 patients with therapy-resistant depressive syndromes of various origins were treated by the infusion of high Hydiphen doses, a very effective thymoleptic drug with no dissociation between its drive increasing and spirit raising actions. The results yielded by this treatment varied from good to very good in respect of endogenic depressions, in which the mood was observed to change at doses between 150 and 425 mg/d, depending on the severity of the depression. The results of this treatment were less satisfactory in the case of reactive and bran-organically induced depressions.

[Study approach and initial results of the effect of sleep deprivation on the depressive syndrome]. / Untersuchungsansatz und erste Ergebnisse zur Wirkung des Schlafentzugs beim depressive Syndrom.

After a brief review of previous investigations into the antidepressant effect of sleep withdrawal, attention is drawn to problems arising from simultaneous treatment with antidepressants. A method for recording the effects of sleep withdrawal alone is also described. The results indicate that treatment by partial withdrawal of sleep during the second half of the night, tends to have a positive effect on the symptoms of depression and on the psychophysical status of the patients. The author concludes with an overview of the problems still outstanding.

[Quantitative amino acid determination in the serum and cerebrospinal fluid in endogenous depressions]. / Quantitative Aminosäuren-bestimmungen im Serum und Liquor bei endogenen Depressionen.

The levels of 20 amino acids were measured in the plasma and cerbrospinal fluid of 41 patients with endogenic depressions. The plasma levels of 12 amino acids were found to be significantly lower in the patients than in the control group, but cerebrospinal fluid levels were significantly lower only in the case of taurine, glutamine, phenylalanine and aginine. Comparison of the same amino acid levels in treated and non-treated patients showed that serine and alpha-aminobutyric acid serum concentrations were higher in the nontreated patients. The tyrosine and phenylalanine levels in the cerebrospinal fluid of the patients who had received medicamentous treatment were higher than in the other group.