[Functioning biological activity of mean mineralized sodium bicarbonate in water from the "Pitoniakówka" source in Szczawnica, designed for health resort potable cures]. / Czynne dzialanie biologiczne sredniozmineralizowanej wody wodoro-weglanowo-sodowej z ujecia "Pitoniakówka" w Szczawnicy, przeznaczonej do uzdrowiskowej kuracji pitnej.

In the experiments on animals the biological activity of the water from its intake "Pitoniakówka" (outflow B + C + D + G) in Szczawnica has been determined. The basic investigations were carried out on rats whom in the course of 24 days the investigated water was being administered to drink ad libitum or by probe in a single daily dose of 10.7 ml/kg of body weight. It has been ascertained that the water caused a statistically significant increase of the concentration of sodium and a fall of the levels of potassium, magnesium, calcium, total cholesterol, the HDL fraction of cholesterol, total lipids in the blood serum, also of hematocrit, hemoglobin and erythrocytes. The investigated water inhibited the motor activity of the small intestine of the rabbit, caused increased urination and increased water turnover in the organism. A long-lasting application of the investigated water may lead to the genesis of metabolic acidosis. There was not observed any cholagonic and any chologenic activity of the investigated water in guinea pigs or any effect of that water on the elements of the carbohydrate metabolism, the protein metabolism or on the peripheral blood smear in rats.

[Investigation of the pharmacodynamic properties of the solution of boric acid]. / Badanie wlasciwosci farmakodynamicznych roztworu kwasu borowego.

By virtue of experimental investigations that had been carried out on animals an essential biological action of the aqueous solution of boric acid on the organism could be stated. The solution containing 274.46 mg of H3BO3 in a litre, administered to rats for 30 days orally in an "ad libitum" dose, caused changes in the lipid metabolism and in the water-mineral balance of the organism and in the acid-base equilibrium of the blood, it did not affect the morphology and the parameters of carbohydrate and protein metabolism. No influence has been stated of the investigated boric acid, as used in guinea pigs, on the excretion of bile. Suitably diluted with a nutritive fluid the solution acted spastically on the peristalsis of the small intestine of the rabbit.

[Evaluation of pharmacodynamic properties of medium-mineralized alkaline water designed for distribution as bottled natural mineral water]. / Ocena wlasciwosci farmakodynamicznych sredniozmineralizowanej wody alkalicznej przeznaczonej do dystrybucji jako butelkowana naturalna woda mineralna.

Basing on the carried-out investigations it has been shown that the alkaline water from "Paproc" source in Tymbark indicates a biological activity. Applied in rats orally, in an appropriate dose through the period of 30 days, it causes a statistically significant increase of the pH of urine and blood, of the level of uric acid in urine and a statistic lowering of the levels of calcium and potassium in the blood serum. The investigated water shows diuretic activity, neutralizes and inhibits gastric juice secretion in people, affects the peristaltic movements of the smooth muscles of the small intestine of the rabbit. No effect of that water on the elements of the protein metabolism, the fat metabolism, on the smear and the morphological composition of the peripheral blood of rats, on the excretion of bile in guinea pigs has been observed.

[Evaluation of the biological action of the fluoride waters applied in the form of the potable cure in experimental animals]. / Ocena dzialania biologicznego wód fluorkowych stosowanych w postaci kuracji pitnych u zwierzat doswiadczalnych.

Basing on the carried out investigations it has been shown that the fluoride water from the spring "Zdzislaw" from Ladek Zdrój and the aqueous solution of NaF in the F concentration like that in the curative water, used in rats intragastrically in a single daily dose of 14.3 ml/kg of body weight or ad libitum for a period of 20 days, brought about a statistically significant decrease of whole cholesterol, of the HDL fraction of cholesterol, of whole lipids, triglycerides, sodium and magnesium and about an increase of potassium and calcium in the blood serum as compared with the control group of animals. Observed at the same time were changes that testified to the occurrence of respiratory decompensated acidosis and alkalosis. No essential influence of the investigated waters on the protein, carbohydrate metabolism, smear and the morphological composition of the peripheral blood and on the bone marrow smear could be stated. The investigated waters acted spastically on the smooth muscles of the small intestine of the rabbit, they were showing diuretic action in the rats and caused an increased water turnover in the organism.

[A determination of iodides in salts: a validation of methods]. / Oznaczanie jodków w solach--walidacja metod.

The studies reported were aimed at finding a simple analytical method enabling quantitative determination of iodide in table iodised salt and in therapeutic iodide-bromide salts. The analytical procedure proposed is a modification of spectrophotometric method recommended in the Polish Standards. The method based on the reaction of iodide oxidation by sodium nitrite was validated by determining its precision, accuracy and linearity. Statistical analysis has shown that the coefficient of variation varies between 2.73 and 4.82%, recovery is from 99.17 to 101.83% and falls within the confidence interval for the mean recovery at the assumed level of significance. The method can be used for controlling the technology of table salt iodisation.

[Some pharmacodynamic properties of the "Marysiennka" healing water from the Cieplice-Zdrój springs]. / Niektóre wlasciwosci farmakodynamiczne wody "Marysienka" ze zródla w Cieplicach-Zdroju.

On the ground of the performed experimental investigations it has been shown that the "Marysienka" water, given to rats intragastrically in a single daily dose of 14.3 cm3/kg body weight for the spans of 20 and 40 days and in the some spans of time as drinking water ad libitum, causes a statistically significant decrease of the levels of total cholesterol, total lipids, triglycerides, and an increase of the HDL fraction of cholesterol. Within the range of the investigated parameters of electrolytic economy a statistically significant fall of the level of calcium and decrease tendencies of sodium, magnesium and increase tendencies of potassium in the blood serum of the examined animals could be observed. After 20 days of the administration of the investigated water both intragastrically in a single daily dose of 14.3 cm3/kg body weight and in the animals that were receiving that water as drinking water ad libitum a marked compensated metabolic acidosis was observed. A long-lasting exposition of the rats (40 days) to that water may lead to the rise of compensated metabolic alkalosis. No essential influence of the studied water on the indicators of protein and carbohydrate metabolism and on the morphological composition of the peripheral blood and its smear was noted. The studied water shows no cholagogic effect in guinea-pigs, nor any diuretic effect in rats.

[Suitability of the direct potentiometric method with the use of ion-selective electrodes for the evaluation of iodide ions in iodized table salt]. / Badanie przydatnosci metody potencjometrii bezposredniej z uzyciem elektrody jonoselektywnej do oznaczania zawartosci jodków w spozywczej soli jodowanej.

The usefulness of the direct potentiometric method with an ion-selective electrode for determination of iodide ions in the iodised table salt was checked. The changes in the EJ-01 iodide electrode potential versus the concentration of J- ions in water solutions of potassium iodide and different amounts sodium chloride were studied. On the basis of the electrode calibration curves the ranges of detectability and correct determination as well as the sensitivity of the electrode were established. The studies were performed in solutions of natural iodised table salt with and without and internal standard. The results have proved that this method is unsuitable for determination of the content of J- ions in the commonly used iodised table salt.

[The safety and usefulness of transgenic plants]. / Bezpecnost a prospesnost transgenních rostlin pro cloveka.

Transgenic crop plants, used in food and feed production, carry different beneficial transgenes, mostly for resistance to pests, herbicides and diseases. All new transgenic plant varieties, the genes they carry and their products have been thoroughly tested before released for agriculture and even more for marketing. Genetically modified organisms carry the same risk as any other organism. Food derived from genetically modified organisms due to legal regulation is most controlled and therefore most safe food ever placed on the market. In future, transgenic plants offer many new possibilities also for medical use, like plant vaccines, antibiotics and rare proteins of clinical importance produced by plants.

[The influence of natural peat and isolated humic acid solution on certain indices of metabolism and of acid-base equilibrium in experimental animals]. / Wplyw borowiny naturalnej i roztworu izolowanych kwasów huminowych na niektóre wskazniki przemiany materii i równowagi kwasowo-zasadowej u zwierzat doswiadczalnych.

The biological effect in rats treated with natural peat homogenate and isolated humic acids has been shown in pharmacodynamic studies. After 24 days of this treatment decrease of total cholesterol, total lipids, an increase of HDL fraction of cholesterol, decrease in glucose level and increase of protein fraction of globulin, hemoglobin, hematocrit and total number of erythrocytes were observed. The treatment did not influence the electrolyte equilibrium. However, after the treatment with humic cides the respiratory acidosis not compensated with the metabolic component was observed. The activity of the natural peat was more favorable as compared to the activity of humic acids solution.