ABSTRACT
Alemtuzumab is effective in relapsing remitting multiple sclerosis (RRMS). Serious adverse events have led to a renewed safety reassessment by the European Medicines Agency (EMA), leading to an approval under strict conditions. We report a RRMS patient experiencing diffuse alveolar hemorrhage (DAH) on day 4 of her first alemtuzumab cycle. In addition, we present an overview of the cases of alemtuzumab-induced DAH that were included in EMA's review procedure, additional well documented cases reported to the EMA and those cases reported in the literature. Combining these cases revealed striking similarities. Importantly, DAH was an early complication. All RRMS patients with known outcome showed complete recovery.
Subject(s)
Lung Diseases , Multiple Sclerosis, Relapsing-Remitting , Multiple Sclerosis , Alemtuzumab/adverse effects , Female , Hemorrhage/chemically induced , Humans , Multiple Sclerosis, Relapsing-Remitting/drug therapyABSTRACT
The study presents the history of scientific research of caries incidence on the basis of the archaeological and excavated remains and other historical sources. The analysis of teeth curing was carried out on historical grounds covering early ancient and medieval methods as well as contemporary ways of caries prevention.
Subject(s)
Dental Caries/history , Dental Caries/epidemiology , Dental Caries/therapy , Europe/epidemiology , History, 16th Century , History, 19th Century , History, 20th Century , History, Ancient , History, Medieval , Humans , Incidence , Poland/epidemiologyABSTRACT
The development of teaching stomatology in Poland during the loss of independence, between the two World Wars and after the Second World War has been presented in this study. Stomatology was a specialization practised by physicians who were educated in diseases of teeth and oral cavity. Nowadays stomatology is the department of the Faculty of Medicine at all Medical Universities. Dentists are licensed to practise dentistry and to get specialization grades and university degrees.
Subject(s)
Education, Dental/history , Oral Medicine/history , History, 20th Century , Oral Medicine/education , Poland , Teaching/historyABSTRACT
The study presents the state of the permanent dentition in 18-year-olds from the rural population. The results show DMF 9.08 which is higher for women (10.66) than for men (7.50). The highest value of DMF has been found in molar teeth which are filled and extracted most often. The health needs concerning filling of teeth are higher in women than in men, they are higher in maxilla than in mandibula. The endodontic health and extraction needs are higher in women than in men; for both sexes they are higher in maxilla and it concerns lateral teeth.
Subject(s)
DMF Index , Adult , Dental Health Surveys , Female , Humans , Male , Poland , Rural Health , Sex Characteristics , Tooth Extraction/statistics & numerical dataABSTRACT
On 238 intra-oral roentgenograms there were assessed carious process, shape, size, extent and depth of defects as well as the possibility of complications in teeth which were not treated. There were assessed 277 defects, out of which 194 in upper teeth and 83 in lower ones. In all the teeth of the maxilla and of the mandible there was found the greatest number of amorphic defects and semilunar contact surfaces. There were also observed a lot of defects in radiciform cementum, thus, often under the gingivae. These are sites difficult for access for clinical examination. That is why radiologic examination is often conclusive in localizing carious process and in accurate diagnosing in the case of pulpitis going on.