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1.
Rev Med Interne ; 42(7): 509-512, 2021 Jul.
Article in French | MEDLINE | ID: mdl-33846035

ABSTRACT

INTRODUCTION: Propylthiouracil (PTU) is a synthetic antithyroid drug that can induce ANCA-associated vasculitis. OBSERVATION: A 27-year-old woman diagnosed with Graves' disease was on PTU for the past 10 years. She developed purpuric lesions of the legs and on the tip of the nose diagnosed as vasculitis. ANCAs were positive, with anti-MPO and anti-PR3 on blood ELISA. After discontinuation of PTU, she was able to fully recover. CONCLUSION: All synthetic antithyroid drugs can induce ANCA-associated vasculitis, more often PTU. In most cases, antibodies are directed against MPO. Dual anti-MPO and anti-PR3 positivity is possible, but rare. The mechanism could be through an accumulation of PTU in neutrophils, altering the structure of MPO and making it immunogenic. PTU can also induce ANCA-free or lupus vasculitis, maculopapular rashes or urticaria. Many other drugs can induce ANCA-associated vasculitis.


Subject(s)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis , Hyperthyroidism , Purpura , Adult , Antibodies, Antineutrophil Cytoplasmic , Antithyroid Agents/adverse effects , Female , Humans , Hyperthyroidism/chemically induced , Hyperthyroidism/complications , Hyperthyroidism/diagnosis , Propylthiouracil/adverse effects
2.
Cancer Lett ; 114(1-2): 207-10, 1997 Mar 19.
Article in English | MEDLINE | ID: mdl-9103293

ABSTRACT

We have shown previously that two flavonoids, apigenin and tangeretin, enhance gap junctional intercellular communication (GJIC) in rat liver epithelial cells, named REL cells. Here, we show that these two flavones also antagonize the inhibition of GJIC induced by tumor promoters like 12-O-tetradecanoyl-phorbol-acetate (TPA) and 3,5,di-tertio-butyl-4-hydroxytoluene (BHT). Their preventive effect is rapid. It does not seem to involve any change of the amount of the connexin expressed in REL cells, connexin 43 (Cx 43), and in its phosphorylation state. Other flavonoids tested including naringenin, myricetin, catechin and chrysin did not enhance GJIC nor counteract TPA-induced inhibition of GJIC.


Subject(s)
Carcinogens/antagonists & inhibitors , Flavones , Flavonoids/pharmacology , Liver/drug effects , Oils, Volatile/pharmacology , Animals , Blotting, Western , Butylated Hydroxytoluene/pharmacology , Cells, Cultured , Chamomile , Connexin 43/metabolism , Dimethyl Sulfoxide/pharmacology , Epithelium/drug effects , Fluorescent Antibody Technique , Gap Junctions/drug effects , Phosphorylation/drug effects , Plants, Medicinal , Rats , Tetradecanoylphorbol Acetate/pharmacology
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