Subject(s)
Cardiovascular Diseases/prevention & control , Lipoproteins, HDL/physiology , Lipoproteins, LDL/physiology , Cardiovascular Diseases/blood , Cardiovascular Diseases/etiology , Health Services Needs and Demand , Humans , Hypolipidemic Agents/therapeutic use , Inflammation , Life Style , Practice Guidelines as Topic , Primary Prevention , Risk Reduction BehaviorSubject(s)
Diabetes Mellitus, Type 2/prevention & control , Hypoglycemic Agents/therapeutic use , Metformin/therapeutic use , Diabetes Mellitus, Type 2/diagnosis , Diabetes Mellitus, Type 2/epidemiology , Diabetes Mellitus, Type 2/etiology , Early Diagnosis , Female , Humans , Hypoglycemic Agents/pharmacology , Insulin Resistance , Life Style , Male , Metabolic Syndrome/complications , Metformin/pharmacology , Obesity/complications , Polycystic Ovary Syndrome/complications , Risk Factors , Risk Reduction Behavior , Treatment Outcome , United States/epidemiologySubject(s)
Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Aspirin/administration & dosage , Cardiovascular Diseases/prevention & control , Cyclooxygenase Inhibitors/administration & dosage , Patient Selection , Platelet Aggregation Inhibitors/administration & dosage , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Aspirin/adverse effects , Cyclooxygenase Inhibitors/adverse effects , Drug Administration Schedule , Hemorrhage/chemically induced , Humans , Platelet Aggregation Inhibitors/adverse effects , Risk Factors , Safety , Treatment OutcomeSubject(s)
Diabetes Complications/complications , Hyperlipidemias/complications , Cause of Death , Diabetes Complications/mortality , Diabetes Complications/prevention & control , Global Health , Humans , Hyperlipidemias/mortality , Hyperlipidemias/prevention & control , Hypolipidemic Agents/therapeutic use , Practice Guidelines as Topic , Risk FactorsSubject(s)
Genetic Testing/organization & administration , Neonatal Screening/organization & administration , Population Surveillance/methods , Genetic Carrier Screening , Genetic Predisposition to Disease/epidemiology , Genetic Predisposition to Disease/genetics , Health Policy , Humans , Infant, Newborn , Organizational Objectives , Predictive Value of Tests , Public Health Practice , Risk Assessment/organization & administrationABSTRACT
Recent discovery and characterization of APOAV suggests a role in metabolism of triglyceride (TG)-rich lipoproteins. Previously, variation at the APOAV locus was shown to modestly influence plasma TGs in normolipidemic samples. The aims of this study were to assess the effects of a polymorphism in APOAV (T-1131C) in terms of its frequency among three dyslipidemic populations and a control population, differences of allele frequency across available ethnic groups, and associations with specific lipoprotein TG and cholesterol compartments. We found a striking elevation in the frequency of the rare allele in a Chinese population (P = 0.0002) compared with Hispanic and European populations. The rare allele of the polymorphism was associated with elevated plasma TG (P = 0.012), VLDL cholesterol (P = 0.0007), and VLDL TG (P = 0.012), LDL TG (P = 0.003), and HDL TG (P = 0.016). Linear regression models predict that possession of the rare allele elevates plasma TG by 21 mg/dl (P = 0.009) and VLDL cholesterol by 8 mg/dl (P = 0.0001), and reduces HDL cholesterol by 2 mg/dl (P = 0.017). The association of the polymorphism with altered lipoprotein profiles was observed in combined hyperlipidemia, hypoalphalipoproteinemia, and hyperalphalipoproteinemia, and in controls. These findings indicate that APOAV is an important determinant of plasma TG and lipoprotein cholesterol, and is potentially a risk factor for cardiovascular disease.