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Pediatr Blood Cancer ; 52(3): 396-8, 2009 Mar.
Article in English | MEDLINE | ID: mdl-18989884

ABSTRACT

The anti-Hu syndrome is a well-known paraneoplastic syndrome and may be rarely seen in patients with neuroblastoma. However, it is relatively unknown that anti-Hu antibodies can cause gastro-intestinal signs and symptoms. We report on a child with neuroblastoma who presented with gastro-intestinal disturbances as a result of the anti-Hu syndrome and summaries two similar case reports reported in literature. Neuroblastoma patients with gastro-intestinal disturbances, ranging from constipation to a paralytic ileus, might suffer from the gastro-intestinal anti-Hu syndrome. The causative antibodies can be determined to diagnose or exclude this syndrome, and successful treatment is possible.


Subject(s)
Autoantibodies/immunology , ELAV Proteins/immunology , Gastrointestinal Diseases/complications , Gastrointestinal Diseases/diagnosis , Neuroblastoma/complications , Paraneoplastic Syndromes/complications , Paraneoplastic Syndromes/diagnosis , Autoantibodies/analysis , Child, Preschool , Gastrointestinal Diseases/immunology , Humans , Male , Neuroblastoma/diagnosis , Paraneoplastic Syndromes/immunology
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