[Immunological research in cryptorchism accompanied by infertility]. / Immunologicheskie issledovaniia pri kriptorkhizme, soprovozhdaiushchemsia infertil'nost'iu.

An overview of the recent literature shows that immune processes, primarily autoimmune events, occur in cryptorchid patients with infertility. The aim of this study was to examine cellular and systemic immune responses in these patients. Fifteen infertile cryptorchid patients have been investigated for the presence of circulating autoantibodies using immunofluorescence and immunoperoxidase techniques. The study evaluated selected testicular structures and levels of immune products (IgA, IgG, IgM or immune complexes) in testicular biopsy samples. The results of the study showed no relation of infertility to systemic immune disturbance in most cryptorchid patients.

[Mastocytes in the human intestinal mucosa]. / Prouchvane na mastotsitite v choveshka chrevna ligavitsa.

A method has been for counting the mastocytes on 0.1 mm2 of intestinal mucosa in patients with chronic enterocolitis, gluten enteropathy, ulcerous colitis in a stage of exacerbation and in controls. The comparison of the results obtained in the separate groups of patients reveal an increased number of mastocytes in gluten enteropathy--mean = 21.01 +/- 6 as compared with the chronic enterocolitis, where mean = 9.79 +/- 3.83 (p = 0.002). Higher values of mastocytes in rectal mucosa were observed in the patients with ulcerous mucosa--mean = 15.83 +/- 4.49 as compared with the control subjects with means = 3.67 +/- 0.99 (p = 0.001). those data admit the participation of mastocytes in the morbid process in patients with gluten enteropathy and with ulcerous colitis.

[Parallel morphological, enzyme and immunological research on the jejunal mucosa in patients with gluten enteropathy, chronic nonspecific enteritis and ulcerative colitis]. / Paralelni morfologichni, enzimni i imunologichni izsledvaniia na ieiunalnata ligavitsa pri bolni s glutenova enteropatiia, khronichen nespetsifichen enterit i iazven kolit.

The results are reported from the study on 120 patients, 30 of them with gluten enteropathy, 50--with chronic unspecified enteritis and 40--with chronic ulcerous colitis. Small intestinal aspiration biopsy was performed to all patients with histomorphological, electron microscopic, enzymatic and immune-fluorescent study. The secretory immunoglobulins in the jejunal juice were studied in 40 patients. Morphological changes, various degrees, were established, that correlate with the increased number of IgG and IgM secretory cells. The exclusion of gluten from the diet in case of gluten enteropathy was followed by normalization of the number and percentage ratio of IgSC and of secretory immunoglobulins. The enzymatic and immune disorders, in chronic unspecific enteritis correlate with the electron microscopic and precede the histologic ones. The role of immune system of small intestine in the etiology and pathogenesis of the various intestinal diseases is discussed.

[Correlation between immunoglobulin-secreting cells and secretory immunoglobulins in the small intestine in chronic intestinal diseases]. / Korelatsiia mezhdu imunoglobulin-sekretirashtite kletki i sekretornite imunoglobulini v tunkite cherva pri niakoi khronichni chrevni zaboliavaniia.

A total of 45 patients were studied: seven with gluten enteropathy and 38 with chronic unspecific enteritis. Histological and immunefluorescent studies were performed and to a part of the cases--enzymatic and electron-microscopic investigations of the jejunal mucosa. An increased number of immuneglobulin -secreting cells was established in the non-treated patients with gluten enteropathy, growing with age. In the cases with chronic unspecific enteritis with a manifested clinic, a tendency to decrease of the number of IgSC was observed, with growing percentage of IgG-SC and the values of the secretory IgG. There was no correlation between the intraepithelially located lymphocytes and those in the chorion, as well as between the duration of the disease, number and percentage distribution of Ig-SC.