[Mechanisms disordering wound healing on the lip after bilateral crossing of the inferior alveolar nerve and experimental validation of correction methods]. / Mekhanizmy narusheniia zazhivleniia rany guby posle dvustoronnei pererezki nizhneal'veoliarnogo nerva i obosnovanie metodov korrektsii v éksperimente.

The mechanisms of lip wound healing after bilateral crossing of the inferior alveolar nerve (IAN) were studied on Chinchilla rabbits in 3 experimental series, 6 animals per series. In group 1 bilateral crossing of IAN was carried out, in group 2 bilateral crossing of IAN was paralleled by removal of a mucous flap in the middle of the lower lip, and in group 3 the same wound as in group 2 was created, after which the wounds in this group were daily treated with a special ointment and a single injection of lidocaine (1% solution) under the wound. The nerve crossing led to development of ulcer on the lip with degenerative changes in the vascular walls, destruction of nerve fibers, and fragmentation of some axial cylinders. Crossing of IAN simultaneously with removal of the lower lip flap led to more severe degenerative changes in the tissue. Daily treatment of the lip with the ointment and lidocaine blocking normalized wound healing. A possible mechanism of the changes observed is discussed.

[The structural characteristics of the bony tissue at the surface of an implant with hydroxyapatite spray-coated with excimer and CO2 lasers]. / Osobennosti postroeniia kostnoi tkani u poverkhnosti implanta s pokrytiiami iz gidroksiapatita, napylennymi éksimernym i CO2-lazerami.

Rat experiments were performed to study osteogenesis and osseointegration in implanting fragments of dental titanic implants into the spongy bone. The implant spray-coating with hydroxyapatite produced by excimer and CO2 lasers stimulates osteogenesis. Bone tissue integration with implant proceeds more actively in response to CO2 laser radiation. The weakest integration was registered between the metal and bone tissues.

[The characteristics of the wound-healing action of solubilized alpha-tocopherol acetate]. / Osobennosti ranozazhivliaiushchego deistviia soliubilizirovannogo al'fa-tokoferola atsetata.

The rat experiments were made to compare the wound-healing action of solubilized (aqueous) alpha-tocopherol acetate (SATA) prepared by the original techniques and its official oil-based preparation. A course intravenous SATA (2 mg four times at an interval of 4 days) administration was found to stimulate epithelial regeneration and suppress the formation of connective tissue of uncomplicated skin wounds. By healing the complicated wounds, SATA potentiated the occurrence of an inflammatory reaction and slowed down regeneration, whereas its oily solution failed to produce this effect.

[Use of a new M-cholinolytic drug KG-62 for correction of the course of experimental stomach ulcer]. / Primenenie novogo M-kholinoliticheskogo preparata KG-62 dlia korrektsiitecheniia éksperimental'noi iazvy zheludka.

The preparation KG-62 related to iodomethylates of hydroxyalkyl phosphinic acids with muscarinolytic effect has been studied. The study provides data on the development of experimental gastric ulcer among rats after injections of the preparation. On the basis of morphologic, morphometric and biochemical data it has been stated that the preparation KG-62 in a 5 mg/kg dose has a more strong effect leading to quick gastric ulcer healing. It was supposed that not only suppressing action on hydrochloric acid and pepsinogen secretion lies in the mechanism of the effect but also the activation of physiologic regulation in intact tissue.