[Assessment of the level of immunoglobulin E in patients with pyo-inflammatory diseases and its influence on the course of the infectious process].

The level of immunoglobulin E (IgE) in patients with different pyo-inflammatory diseases was assessed and it was found to elevate in patients with acute appendicitis in 49% of cases, in patients with chronic relapsing furunculosis (CRF) in 41%, with chronic osteomyelitis--in 66.6%. In 8 out of 16 examined patients with the elevated level of IgE there were antibodies to toxocars in titers 1:800, 1:400. No correlation with the IgE level was found in assessing the level of IL-4 and gamma-IFN in blood serum of patients with CRF. In patients with acute appendicitis, CRF and chronic osteomyelitis the elevated level of IgE can be considered as a marker of unfavorable course of pyo-inflammatory diseases. The elevated level of IgE does not influence the oxygen-dependent mechanisms of bactericidal action of neutrophils.

[The Siberian and Far-Eastern subtypes of tick-borne encephalitis virus registered in Russia's Asian regions: genetic and antigen characteristics of the strains]. / Sibirskii i dal'nevostochnyi podtipy virusa kleshevogo éntsefalita v evropeiskikh i aziatskikh regionakh Rossii: geneticheskaia i antigennaia kharakteristika shtammov.

Agar gel precipitation test with cross-adsorbed immune sera was used for the antigenic differentiation of strains of tick-borne encephalitis virus (TBEV). Fifty strains of the Far East TBEV serotype and 46 strains of the Siberian (Aina) TBEV serotype were isolated from Ixodes persulcatus, which is the main vector of the above TBEV subtypes in the Asian and European parts of Russia. The fragment of the envelope protein gene was sequenced for TBEV strains. Sequences of new-group strains of the Siberian subtypes isolated from 3 patients with chronic TBE and from brain tissues of 4 deceased patients were determined. Lethal TBE outcomes were registered in Siberia (Irkutsk Region and Krasnoyarsk Territory) and in Russia's European part (Yaroslavl Region).

[Tick-borne borreliosis in the Iaroslavl region]. / Kleshchevoi borrelioz v Iaroslavskoi oblasti.

The present paper characterizes a natural focus of tick-borne borreliosis in the Yaroslavl Region, analyzes the incidence of this infection in the Region, and thus concludes that the density of the population living in the areas of the natural foci of tick-borne borreliosis has a significant impact on its epidemic process. The incidence of tick-borne borreliosis in the Yaroslavl Region has remained a challenge in the past 7 years. By the number of cases, this infection heads the list of naturally focal infections recorded in the Region. Examining long-term changes in the incidence and prevalence of tick-borne borreliosis in the Region revealed its high incidence in the population residing in the tidal marshlands and forest areas. At the same time the potential activity of natural foci of borreliosis due to the conditions that maintain the population of Ixodes ticks is high in the forest-field, southern, and meadow-forest-field regions.

[Content of total immunoglobulin E in patients with acute appendicitis]. / Soderzhanie obshchego immunoglobulina E u bol'nykh s ostrym appenditsitom.

The authors investigated the content of total immunoglobulin E in 34 patients with different forms of acute appendicitis. Higher level of immunoglobulin E was revealed in 19 patients. All the patients had destructive forms of appendicitis, in the third of the patients they were complicated by the development of local peritonitis or by spread of the inflammation outside the appendix. The postoperative period in patients with the elevated level of immunoglobulin E was characterized by a higher incidence of purulent wound complications which can be accounted for by the initially more severe forms of lesions of the appendix.

[Progressiveness of schizophrenia. II. The progressiveness of continuously proceeding forms of schizophrenia]. / K probleme progredientnosti shizofrenii. Soobshcheniee II. K probleme progredientnosti nepreryvno tekushchikh form shizofrenii.

The study involved a clinical examination of 568 patients with continious forms of schizophrenia and different degrees of progression (from mild sluggish to malignant forms). The following stages of the diseases are differentiated: an initial one, a stage of the highest process activity, a stage of stabilization, reduction of the psychosis and formation of the terminal state. A thorough analysis of the cases demonstrated that even in a continuous development of schizophrenia, the progression of the process is limited in time. It was found that the more polymorphic and severe are the signs of the process in active phase, the less is the time taken by this phase. In compliance with varying duration of the active stages of the disease the age periods during which there ensue a stabilization of the malignant, sluggish and paranoid forms of schizophrenia are very diverse.

[Age patterns in the dynamics of unfavorably developing forms of schizophrenia in the light of late follow-ups in old age]. / Zakonomernosti vozrastnoi dinamiki neblagopriiatno protekaiushchikh form schizofrenii v svete otdalennykh katamnezov v starosti.

On the basis of study of 376 elderly patients it was established that the progression of the schizophrenic process, even in unfavorably developing forms (continuous-progressive, attacklike becoming continuous and attacklike with protracted attacks) in most of the cases is not unlimited. The greatest activity of the morbid process is seen in middle age and in the involutional period, while its alleviation (irrespective of age of the disease onset) coincides with senescence. These data may facilitate an establishment of a long-term prognosis and determine the correct therapeutic and social measures in relation to patients of old age.

[Problem of progression in schizophrenia. I. Problem of progression of attack-like forms]. / K probleme progredientnosti pri shizofrenii. Soobshchenie I. K probleme progredientnosti pristupoobrazno protekaiushchikh form.

A total of 552 patients with attack-like schizophrenia, who attained old age were examined clinically. It was established that the development of negative changes in such patients occurs predominantly during the first half of life. Subsequently not all patients demonstrate a progressive development of the disease and even if it does occur it is seen in the form of more frequent or longer attacks and a complication of psychopathological disorders. At the same time there is a certain correlation between the clinical picture of the attacks and the severity of deficitary changes. A reverse development of some personality changes in long-term remissions in old age are described.

[Comparative analysis of attack-like schizophrenia in light of remote catamnesis in old age]. / Sravnitel'nyi analiz pristupoobraznoi shizofrenii v svete otdalennykh katamnezov v starosti.

On the basis of a comparative clinico-catamestic study of 193 patients with attack-like schizophrenia and a different degree of progressiveness the authors describe the most common traits in the development of the attack-like process. The report contains data related to different tendecines in the course of the disease, its age dynamics and some correlations between the degree of progressiveness and separate clinical parameters. It was established that the most expressed negative personality changes are formed in the initial periods of the disease and to a large extent determine the traits in the course of the disease.

[Results of a continuous study of a population of schizophrenic patients more than 60-years-old, registered at Moscow Psychoneurologic Dispensary No. 2]. / Rezul'taty sploshnogo obsledovaniia populiatsii bol'nykh schizofreniei starshe 60 let, nakhodiashchikhsia na uchete v Moskovskom psikhonevrologicheskom dispansere No. 2

The authors conducted an overall study of schizophrenic patients, older than 60 years of age and registered in one of the Moscow dispensaries. It was demonstrated that the elderly amount to 17% of the whole schizophrenic population in the given dispensary. The percentage of late schizophrenia (16.7%) is relatively high, although the percentage of them in a hospital population is even higher (27-35%). The sex ratio demonstrated a larger amount of women (1 : 3). 90% of all the studied patients at the moment of examination were at home, while 33% were never admitted to hospitals. Among the studied contingent there was a high percentage of patients with a regressive development of the process and a stabilization with a tendency towards its obliviation. The study contains some data necessary for further investigations concerning the adaptational possibilities and physical state of these patients. The obtained information require correlations with data on the general population of this region in the same age periods.