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1.
A new cyano-substituted anthracycline metabolite from Streptomyces sp. HS-NF-1006.
Wan, Xu; Ren, Hui-Jun; Du, Min-Na; Qi, Huan; Zhang, Hui; Chen, An-Liang; Wang, Ji-Dong.
J Antibiot (Tokyo) ; 70(2): 219-221, 2017 02.
Article in English | MEDLINE | ID: mdl-27599767

Subject(s)
Anthracyclines/chemistry , Anthracyclines/metabolism , Streptomyces/metabolism , Antineoplastic Agents/chemistry , Antineoplastic Agents/metabolism , Antineoplastic Agents/pharmacology , Cell Line, Tumor , Cell Survival/drug effects , Humans , Molecular Structure
2.
New milbemycin metabolites from the genetically engineered strain Streptomyces bingchenggensis BCJ60.
Li, Jian-Song; Du, Min-Na; Zhang, Hui; Zhang, Ji; Zhang, Shao-Yong; Wang, Hai-Yan; Chen, An-Liang; Wang, Ji-Dong; Xiang, Wen-Sheng.
Nat Prod Res ; 31(7): 780-784, 2017 Apr.
Article in English | MEDLINE | ID: mdl-27748635

ABSTRACT

Two new milbemycin derivatives, 27-methoxylmilbemycin α31 (1) and 27-oxomilbemycin α31 (2), were isolated from the genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were determined by 1D NMR, 2D NMR and HR-ESI-MS spectral analysis, and comparison with previous reports. The acaricidal and nematocidal capacities of compounds 1 and 2 were evaluated against Tetranychus cinnabarinus and Bursaphelenchus xylophilus, respectively. The results showed that the two new macrocyclic lactones 1 and 2 possessed potent acaricidal and nematocidal activities.


Subject(s)
Acaricides/pharmacology , Antinematodal Agents/pharmacology , Macrolides/metabolism , Streptomyces/metabolism , Acaricides/chemistry , Animals , Antinematodal Agents/chemistry , Drug Evaluation, Preclinical/methods , Genetic Engineering , Macrolides/chemistry , Magnetic Resonance Spectroscopy , Molecular Structure , Spectrometry, Mass, Electrospray Ionization , Streptomyces/genetics , Tetranychidae/drug effects
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