Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
J Antibiot (Tokyo) ; 76(12): 728-730, 2023 12.
Article in English | MEDLINE | ID: mdl-37857884

ABSTRACT

Two new isocoumarin derivatives, eleuthemarins A (1) and B (2), were isolated from the Arctic fungus Eleutheromyces sp. CPCC 401592. Their structures and absolute configurations were elucidated through spectroscopic methods, quantum chemical calculations of NMR shifts, and calculated electronic circular dichroism. This is the first report for the chemical investigation of the genus Eleutheromyces. Compounds 1 and 2 showed selective cytotoxic activities against H460, A549, and HCT116 cancer cell lines with IC50 values in the range of 24.1-57.3 µM, respectively. Compound 1 displayed weak antibacterial activities.


Subject(s)
Ascomycota , Isocoumarins , Humans , Isocoumarins/pharmacology , Isocoumarins/chemistry , Anti-Bacterial Agents/chemistry , Magnetic Resonance Spectroscopy , HCT116 Cells , Molecular Structure
SELECTION OF CITATIONS
SEARCH DETAIL
...