1.
Org Biomol Chem
; 14(7): 2195-9, 2016 Feb 21.
Article
in English
| MEDLINE
| ID: mdl-26794806
ABSTRACT
We report an operationally simple, visible-light-driven protocol for intramolecular C-H difluoroacetamidation of arenes for the synthesis of biologically relevant 3,3-difluoro-2-oxindoles at room temperature. Using fac-Ir(ppy)3 as a photocatalyst and a 3 W blue LED as a light source, an array of difluoroxindoles was prepared from rapidly available tertiary aryl bromodifluoroacetamides in moderate to excellent yields.