Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
1.
Nutrients ; 10(6)2018 Jun 07.
Article in English | MEDLINE | ID: mdl-29880750

ABSTRACT

Glutamine is a potent stimulus for the release of glucagon-like peptide-1, which increases postprandial insulin and slows gastric emptying (GE). We determined the effects of glutamine on GE of, and glycaemic responses to, low- and high-nutrient drinks in eight healthy males (mean age 21.6 ± 0.7 years and BMI 22.9 ± 0.7 kg/m²). Participants were studied on four occasions on which they consumed either a low-nutrient (beef soup; 18 kcal) or high-nutrient (75 g dextrose; 255 kcal) drink, each with or without 30 g of glutamine (120 kcal), in a randomised, crossover design. GE (2D ultrasound), blood glucose and plasma insulin concentrations were measured concurrently. Glutamine slowed GE (half emptying time (T50)) of both low- (45 ± 3 min vs. 26 ± 2 min, p < 0.001), and high-nutrient, (100 ± 5 min vs. 77 ± 5 min, p = 0.03) drinks, however, there was no effect on GE of the high nutrient drinks when expressed as kcal/min (3.39 ± 0.21 kcal/min vs. 3.81 ± 0.20 kcal/min, p = 0.25). There was no change in blood glucose after the low-nutrient drinks with or without glutamine, despite a slight increase in plasma insulin with glutamine (p = 0.007). The rise in blood glucose following the high-nutrient drink (p = 0.0001) was attenuated during the first 60 min by glutamine (p = 0.007). We conclude that in healthy subjects, glutamine slows GE of both low- and high-nutrient drinks comparably and attenuates the rise in blood glucose after the high-nutrient glucose drink.


Subject(s)
Blood Glucose/drug effects , Dietary Supplements , Energy Drinks , Gastric Emptying/drug effects , Glutamine/administration & dosage , Nutritive Value , Administration, Oral , Age Factors , Biomarkers/blood , Blood Glucose/metabolism , Cross-Over Studies , Double-Blind Method , Healthy Volunteers , Humans , Insulin/blood , Male , South Australia , Time Factors , Young Adult
2.
Diabetes Care ; 41(3): 627-637, 2018 03.
Article in English | MEDLINE | ID: mdl-29463666

ABSTRACT

If you haven't measured something, you really don't know much about it.-Karl Pearson (attributed)Gastrointestinal (GI) symptoms represent an important and often unappreciated cause of morbidity in diabetes, although the significance of this burden across the spectrum of patients and the underlying pathophysiology, including the relationship of symptoms with glycemic control, remain poorly defined. The relevance of GI symptoms and the necessity for their accurate assessment have increased with the greater focus on the gut as a therapeutic target for glucose lowering. This review addresses the prevalence, assessment, pathogenesis, and management of GI symptoms in diabetes, beginning with broad principles and then focusing on specific segments of the GI tract. We initially performed a literature search of PubMed by using synonyms and combinations of the following search terms: "gastrointestinal symptoms", "diabetes", "prevalence", "pathogenesis", "diagnosis", and "management". We restricted the search results to English only. Review papers and meta-analyses are presented as the highest level of evidence where possible followed by randomized controlled trials, uncontrolled trials, retrospective and observational data, and expert opinion.


Subject(s)
Diabetes Mellitus/epidemiology , Disease Management , Gastrointestinal Diseases/epidemiology , Diabetes Mellitus/diagnosis , Diabetes Mellitus/therapy , Gastrointestinal Diseases/diagnosis , Gastrointestinal Diseases/therapy , Humans , Prevalence , Randomized Controlled Trials as Topic
3.
Diabetes Res Clin Pract ; 135: 73-75, 2018 Jan.
Article in English | MEDLINE | ID: mdl-29133202

ABSTRACT

It remains uncertain if stress hyperglycaemia (SH) indicates a long-term predisposition to the development of type 2 diabetes. We conducted a retrospective observational study in critically ill patients and found SH to be associated with an increased HbA1c, which may indicate an increased risk of type 2 diabetes.


Subject(s)
Anxiety/complications , Critical Illness/mortality , Diabetes Mellitus, Type 2/complications , Glycated Hemoglobin/metabolism , Hyperglycemia/etiology , Anxiety/pathology , Diabetes Mellitus, Type 2/mortality , Diabetes Mellitus, Type 2/pathology , Female , Glycated Hemoglobin/analysis , Humans , Hyperglycemia/pathology , Male , Middle Aged , Retrospective Studies , Risk , Survivors
SELECTION OF CITATIONS
SEARCH DETAIL
...