Palladium-catalyzed enantioselective arylation of trichloro- or tri-/difluoroacetaldimine precursors.

A palladium-catalyzed asymmetric α-arylation of N-carbamoyl imine precursors containing CCl3, CF3 and CF2H is presented. This protocol provides facile access to a series of chiral α-aryl trichloroethylamines bearing various functional groups, with moderate to high yields (40-82% yield) and high enantioselectivity (80-99% ee).

Highly effective and selective FeBr3-promoted deuterium bromination/cyclization of 1,n-enynes.

A highly effective and selective FeBr3-promoted deuterium bromination/cyclization of 1,n-enynes is reported. On the one hand, the Lewis acid FeBr3 as a catalyst promotes cyclization of 1,n-enynes to afford deuterium heterocyclic frameworks with high efficiency. On the other hand, FeBr3 serves as the bromine source (with D2O as the deuterium source) to promote the formation of the desired deuterated pyrrole derivatives containing alkenyl bromide groups. This protocol provides an effective pathway to afford deuterated alkenyl brominative compounds as (Z)-isomers with high yields and selectivity, offering a new method for introducing 2H into organic compounds.