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Am J Obstet Gynecol
; 162(2): 523-4, 1990 Feb.
Article
in English
| MEDLINE
| ID: mdl-2309838
ABSTRACT
Bioavailability of the progesterone antagonist RU 486 was examined in vivo by measurement of first-pass uptake by hepatic and uterine tissues in rats. Presence of human pregnancy serum or alpha 1-acid glycoprotein (orosomucoid) in injection vehicles diminished uptake of this steroid, which suggests limited bioavailability. These data indicate that elevated human serum orosomucoid levels may account for some failures of RU 486 in early pregnancy termination.