ABSTRACT
In language comprehension, listeners expect a speaker to be consistent in their word choice for labeling the same object. For instance, if a speaker previously refers to a piece of furniture as a "couch," in subsequent references, listeners would expect the speaker to repeat this label instead of switching to an alternative label such as "sofa." Moreover, it has been found that speakers' demographic backgrounds, often inferred from their voice, influence how listeners process their language. The question in focus, therefore, is whether speaker demographics influence how listeners expect the speaker to repeat or switch labels. In this study, we used ERPs to investigate whether listeners expect a child speaker to be less likely to switch labels compared to an adult speaker, given the common belief that children are less flexible in language use. In the experiment, we used 80 pictures with alternative labels in Mandarin Chinese (e.g., yi1sheng1 vs. dai4fu, "doctor"). Each picture was presented twice over two experimental phases: In the establishment phase, participants listened to an adult or a child naming a picture with one of the labels and decided whether the label matched the picture they saw; in the test phase, participants listened to the same speaker naming the same picture by either repeating the original label or switching to an alternative label and, again, decided whether the label matched the picture they saw. ERP results in the test phase revealed that, compared to repeated labels, switched labels elicited an N400 effect (300-600 msec after label onset) and a P600 effect (600-1000 msec after label onset). Critically, the N400 effect was larger when listeners were exposed to the child speaker than to the adult speaker, suggesting that listeners found a switched label harder to comprehend when it was produced by a child speaker than an adult speaker. Our study shows that the perceived speaker demographic backgrounds influence listeners' neural responses to spoken words, particularly in relation to their expectations regarding the speaker's label switching behavior. This finding contributes to a broader understanding of the relationship between social cognition and language processing.
ABSTRACT
BACKGROUND: Esophageal atresia (EA) is a life-threatening congenital malformation in newborns, and the traditional repair approaches pose technical challenges and are extremely invasive. Therefore, surgeons have been actively investigating new minimally invasive techniques to address this issue. Magnetic compression anastomosis has been reported in several studies for its potential in repairing EA. In this paper, the primary repair of EA with magnetic compression anastomosis under thoracoscopy was reported. CASE SUMMARY: A full-term male weighing 3500 g was diagnosed with EA gross type C. The magnetic devices used in this procedure consisted of two magnetic rings and several catheters. Tracheoesophageal fistula ligation and two purse strings were performed. The magnetic compression anastomosis was then completed thoracoscopically. After the primary repair, no additional operation was conducted. A patent anastomosis was observed on the 15th day postoperatively, and the magnets were removed on the 23rd day. No leakage existed when the transoral feeding started. CONCLUSION: Thoracoscopic magnetic compression anastomosis may be a promising minimally invasive approach for repairing EA.
ABSTRACT
Acute lung injury (ALI), characterized by an acute onset of severe hypoxemia, is a common and devastating syndrome usually triggered by lipopolysaccharide (LPS) infection from bacteria. This study is intended to explore whether terbutaline can alleviate LPS-induced human pulmonary microvascular endothelial cell (HPMVEC) injury through cAMP/Epac signaling. LPS was utilized to induce ALI in HPMVECs, and after exposure of LPS-induced HPMVECs to terbutaline, the cellular functions including cell viability and apoptosis were measured by cell counting kit-8 and terminal deoxynucleotidyl transferase dUTP nick-end labeling. The protein expression related to cAMP/Epac signaling, apoptosis, and that of tight junction and inflammatory factors were evaluated at the same time. The effects of terbutaline on cellular functions were confirmed again after the addition of antagonists of cAMP and Epac, respectively. The levels of both cAMP and Epac reduced by LPS was concentration-dependently increased by terbutaline. The apoptosis and endothelial cell permeability damage of LPS-induced HPMVECs were enhanced after the addition of KT-5720 and ESI-09. The beneficial effects of terbutaline on alleviating the inflammation and apoptosis in HPMVECs injured by LPS are mediated by cAMP/Epac signaling, and this evidence would demonstrate the potential of terbutaline in the treatment of ALI.
