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1.
Selective knockout of gut bacteria.
Duarte, João H.
Nat Biotechnol ; 2022 Dec 02.
Article in English | MEDLINE | ID: mdl-36460791
2.
Enhancing seed protein content.
Duarte, João H.
Nat Biotechnol ; 2022 Dec 02.
Article in English | MEDLINE | ID: mdl-36460792
3.
Uncovering the global RNA virome.
Duarte, João H.
Nat Biotechnol ; 40(11): 1575, 2022 11.
Article in English | MEDLINE | ID: mdl-36347987

Subject(s)
RNA , Virome , Phylogeny
4.
CAR-T cells tackle autoimmunity.
Duarte, João H.
Nat Biotechnol ; 40(11): 1575, 2022 11.
Article in English | MEDLINE | ID: mdl-36347990

Subject(s)
Autoimmunity , Receptors, Chimeric Antigen , Receptors, Chimeric Antigen/genetics , Immunotherapy, Adoptive , T-Lymphocytes
5.
DNA cages target quantum dots.
Duarte, João H.
Nat Biotechnol ; 34(10): 1036, 2016 10 11.
Article in English | MEDLINE | ID: mdl-27727220
6.
Tracing cell lineages with mutable barcodes.
Duarte, João H.
Nat Biotechnol ; 34(7): 725, 2016 07 12.
Article in English | MEDLINE | ID: mdl-27404885

Subject(s)
Cell Lineage , DNA Barcoding, Taxonomic , Humans , Phylogeny
7.
Experimental arthritis: A chilling link to joint pain and hypersensitivity.
Duarte, João H.
Nat Rev Rheumatol ; 12(3): 134, 2016 Mar.
Article in English | MEDLINE | ID: mdl-26823209
8.
Spondyloarthropathies: IL-17A blockade ameliorates ankylosing spondylitis.
Duarte, João H.
Nat Rev Rheumatol ; 12(2): 72, 2016 Feb.
Article in English | MEDLINE | ID: mdl-26794859

Subject(s)
Antibodies, Monoclonal/therapeutic use , Interleukin-17/antagonists & inhibitors , Spondylitis, Ankylosing/drug therapy , Female , Humans , Male
9.
Rheumatoid arthritis: PIAS3 inhibition blocks FLS activity.
Duarte, João H.
Nat Rev Rheumatol ; 12(2): 70-1, 2016 Feb.
Article in English | MEDLINE | ID: mdl-26729462

Subject(s)
Arthritis, Rheumatoid/pathology , Cell Movement , Fibroblasts/pathology , Molecular Chaperones/metabolism , Protein Inhibitors of Activated STAT/metabolism , Synovial Membrane/pathology , Female , Humans , Male
10.
Rheumatoid arthritis: Osteoclasts and ACPAs--the joint link.
Duarte, João H.
Nat Rev Rheumatol ; 12(2): 69, 2016 Feb.
Article in English | MEDLINE | ID: mdl-26676084

Subject(s)
Arthralgia/immunology , Arthritis, Rheumatoid/immunology , Autoantibodies/immunology , Bone Resorption/immunology , Bone and Bones/immunology , Chemokine CXCL1/immunology , Citrulline/immunology , Hydrolases/metabolism , Interleukin-8/immunology , Nociception/physiology , Osteoclasts/immunology , Animals , Female , Humans , Male
11.
Therapy: HSCT-resetting immune tolerance by boosting TREG cell diversity.
Duarte, João H.
Nat Rev Rheumatol ; 11(12): 681, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26526646

Subject(s)
Autoimmune Diseases/immunology , Autoimmune Diseases/therapy , Bone Marrow Transplantation , Forkhead Transcription Factors/physiology , Inflammation/immunology , Receptors, Antigen, T-Cell/immunology , T-Lymphocytes, Regulatory/immunology , Animals , Female , Humans
12.
Rheumatoid arthritis: Hitting the brakes on ectopic lymphoid structure formation.
Duarte, João H.
Nat Rev Rheumatol ; 11(11): 621, 2015 Nov.
Article in English | MEDLINE | ID: mdl-26481432
13.
Osteoarthritis: Autophagy prevents age-related OA.
Duarte, João H.
Nat Rev Rheumatol ; 11(12): 683, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26481437

Subject(s)
Autophagy/genetics , Cartilage, Articular/metabolism , Chondrocytes/metabolism , Microtubule-Associated Proteins/genetics , Osteoarthritis/genetics , Animals
14.
Autoimmunity. Antigen presentation by B cells contributes to murine lupus.
Duarte, João H.
Nat Rev Rheumatol ; 11(10): 564, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26324861

Subject(s)
Antigen Presentation/immunology , B-Lymphocytes/immunology , Genes, MHC Class II/immunology , Histocompatibility Antigens Class II/genetics , Lupus Erythematosus, Systemic/immunology , Animals
15.
Autoimmunity. IRF5 mediates joint inflammation.
Duarte, João H.
Nat Rev Rheumatol ; 11(10): 562, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26369611

Subject(s)
Adaptor Proteins, Vesicular Transport/genetics , Arthritis, Experimental/genetics , Arthritis, Rheumatoid/genetics , Interferon Regulatory Factors/genetics , Membrane Glycoproteins/genetics , Myeloid Cells/metabolism , Toll-Like Receptor 3/genetics , Toll-Like Receptor 7/genetics , Animals
16.
Therapy: New fusion protein reduces IL-1-mediated inflammation.
Duarte, João H.
Nat Rev Rheumatol ; 11(9): 503, 2015 Sep.
Article in English | MEDLINE | ID: mdl-26241188

Subject(s)
Arthritis, Gouty/drug therapy , Immunoglobulin G/therapeutic use , Interleukin-1beta/metabolism , Recombinant Fusion Proteins/therapeutic use , alpha 1-Antitrypsin/therapeutic use , Animals , Arthritis, Gouty/chemically induced , Arthritis, Gouty/metabolism , Disease Models, Animal , Fatty Acids , Knee Joint , Male , Mice , Mice, Inbred C57BL , Mice, Transgenic , Monocytes/metabolism , Protein Precursors/metabolism , Uric Acid
17.
Therapy: Secukinumab improves symptoms of psoriatic arthritis.
Duarte, João H.
Nat Rev Rheumatol ; 11(9): 503, 2015 Sep.
Article in English | MEDLINE | ID: mdl-26168911

Subject(s)
Antibodies, Monoclonal/therapeutic use , Antirheumatic Agents/therapeutic use , Arthritis, Psoriatic/drug therapy , Female , Humans , Male
18.
Connective tissue diseases: Neutrophil extracellular traps--a mechanism of thrombosis in patients with antiphospholipid syndrome?
Duarte, João H.
Nat Rev Rheumatol ; 11(8): 444, 2015 Aug.
Article in English | MEDLINE | ID: mdl-26150123

Subject(s)
Antibodies, Antiphospholipid/immunology , Antiphospholipid Syndrome/immunology , Extracellular Traps , Neutrophils/immunology , Thrombosis/immunology , Humans
19.
Connective tissue diseases: Large intergenic noncoding RNA linked to disease activity and organ damage in SLE.
Duarte, João H.
Nat Rev Rheumatol ; 11(7): 384, 2015 Jul.
Article in English | MEDLINE | ID: mdl-26055545

Subject(s)
Lupus Erythematosus, Systemic/genetics , Lupus Erythematosus, Systemic/pathology , RNA, Long Noncoding/genetics , Female , Humans , Male
20.
Experimental arthritis: Fullerene nanoparticles ameliorate disease in arthritis mouse model.
Duarte, João H.
Nat Rev Rheumatol ; 11(6): 319, 2015 Jun.
Article in English | MEDLINE | ID: mdl-25939420

Subject(s)
Anti-Inflammatory Agents/pharmacology , Arthritis, Experimental/prevention & control , Fullerenes/pharmacology , Inflammation/prevention & control , Mast Cells/drug effects , Nanostructures/administration & dosage , Animals , Female , Humans
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