Subject(s)
Chromosome Aberrations/genetics , Factor XIII Deficiency/genetics , Genes, Recessive/genetics , Adolescent , Blood Coagulation Tests , Child , Child, Preschool , Chromosome Disorders , Consanguinity , Factor XIII Deficiency/diagnosis , Hemorrhagic Disorders/diagnosis , Hemorrhagic Disorders/genetics , Humans , India , MaleABSTRACT
Hemostatic profile (prothrombin time (PT), thrombin time (TT), kaolin cephalin clotting time (KCCT), plasma fibrinogen, serum fibrin/fibrinogen degradation products (FDP) and platelet counts) was examined in 153 neonates with birth anoxia and 86 with sepsis. Remarkable hemostatic alterations occurred in neonates with severe anoxia and sepsis, while those with moderate anoxia exhibited minimal or no change. Vitamin K administration to anoxic babies showed no improvement in the hemostatic profile after 48-72 hours. The hemostatic alterations were presumably due to incipient disseminated intravascular coagulation (DIC). In spite of the marked coagulation changes, only 3 neonates with sepsis and none of the anoxic newborns presented with clinical bleeding indicating a well balanced hemostatic mechanism.
Subject(s)
Bacterial Infections/blood , Hemostasis , Hypoxia/blood , Blood Coagulation Tests , Female , Fibrin Fibrinogen Degradation Products/metabolism , Humans , Infant, Newborn , Infant, Premature, Diseases/blood , Platelet Count , PregnancySubject(s)
Disseminated Intravascular Coagulation/complications , Asia , Blood Coagulation Tests , Disseminated Intravascular Coagulation/diagnosis , Disseminated Intravascular Coagulation/mortality , Hemorrhage/etiology , Hemorrhage/mortality , Humans , Hypoxia/complications , Hypoxia/mortality , Infant, Newborn , Infections/complications , Infections/mortalityABSTRACT
The present study comprises of 208 term, 159 preterm and 18 post-term neonates born to mothers with no history of drug intake or any disease likely to effect coagulation of the newborn. PT, TT and KCCT were relatively prolonged and plasma fibrinogen reduced to varying degree in newborns (as compared to adults). There was further prolongation of TT and reduction in plasma fibrinogen levels amongst preterm newborns as compared to term babies; TT was more prolonged amongst post-term babies also. PT was significantly more prolonged till 30 weeks of gestation, after which a near plateau was formed. KCCT showed significant improvement after 33 weeks and a further trend to normalisation after 38 weeks of gestation. Serum FDP values showed too much of variation for any meaningful statistical analysis but generally FDPs were higher in preterm babies. Intrauterine growth rate had no significant effect on these parameters amongst preterms - similar values for SGA (small for gestational age), AGA (appropriate for gestational age) and LGA (large for gestational age). On the other hand, amongst term babies SGA neonates had significantly prolonged PT and low plasma fibrinogen as compared to AGA; LGA babies also showed more prolongation of TT as compared to AGA.
Subject(s)
Hemostasis , Infant, Newborn , Embryonic and Fetal Development , Fibrin Fibrinogen Degradation Products/metabolism , Fibrinogen/metabolism , Gestational Age , Humans , Infant, Postmature , Infant, Premature , Infant, Small for Gestational Age , Partial Thromboplastin Time , Prothrombin Time , Thrombin TimeABSTRACT
A sequential study of kaolin cephalin clotting time (KCCT), prothrombin time (PT), thrombin time (TT), plasma fibrinogen and serum FDP was conducted during the first four weeks of life on term and preterm babies. A "physiological dip" of PT and TT was noted inappropriate for gestational age (AGA) babies both term and preterm; in case of KCCT, the dip was significant in term AGA babies only. At the end of four weeks, PT and TT had moderately improved in term babies but showed little improvement in preterm ones; KCCT reached almost an adult value in all babies except in preterm AGA and term LGA (large for gestational age) ones. Plasma fibrinogen showed no "physiological dip" and reached adult level in two to four weeks. Serum FDP levels were appreciably raised in preterm AGA babies only at birth and there too normalised by 72 h.
Subject(s)
Hemostasis , Infant, Newborn , Age Factors , Embryonic and Fetal Development , Fibrin Fibrinogen Degradation Products/metabolism , Fibrinogen/metabolism , Humans , Infant, Premature , Infant, Small for Gestational Age , Partial Thromboplastin Time , Prothrombin Time , Thrombin TimeSubject(s)
Coronary Disease/metabolism , Fibrin Fibrinogen Degradation Products/metabolism , Fibrinogen/metabolism , Fibrinolysis , Angina Pectoris/metabolism , Angina Pectoris/physiopathology , Coronary Disease/physiopathology , Female , Humans , Male , Myocardial Infarction/metabolism , Myocardial Infarction/physiopathology , PrognosisSubject(s)
Thrombocytopenia/blood , Adolescent , Adult , Child , Female , Humans , Male , Platelet Aggregation , Platelet Count , Thrombocytopenia/genetics , Thrombocytopenia/physiopathologySubject(s)
Hemoglobin E , Hemoglobins, Abnormal , Thalassemia/epidemiology , Adolescent , Adult , Child , Child, Preschool , Female , Humans , India , Male , Thalassemia/bloodSubject(s)
Leukemia, Myeloid/immunology , Lymphocyte Activation , Adolescent , Adult , Female , Humans , Lymphocytes/immunology , MaleABSTRACT
Fibrinolytic activity of aqueous humor was tested by the Astrup fibrin plate lysis technique in 7 patients who had chronic simple glaucoma and was compared with a control group of 7 patients with senile cataract. The plasminogen activator content of aqueous humour in glaucoma patients was remarkably reduced; it was not demonstrable in as many as six out of seven patients. The lysis zones in the control group ranged from 110 to 900 mm2 with an average of 423 mm2. The want of aqueous fibrinolytic activity may have a pathogenetic implication for glaucoma since deposition of fibrin in the angle of the eye to depressed fibrinolytic activity could increase resistance to aqueous flow.
