ABSTRACT
Organ-specific alterations of ultrastructure and morphofunctional condition in different organism's tissues, which could evidence of the genetic factors inclusion under the development of different hypoxic condition in organism, were investigated. The dates obtained indicated the marked organ-specific "structure" reaction of tissues, cells and organelles under various exogenous influences. Such reactions confirm the presence of different genes expression which account for ultrastructure alterations; its activity is determined by a type, intensity, duration of influence as well as organ belonging. Ultrastructural alterations are mainly determined by tissue and cell factors but not by genetically determined system reactions; it is confirmed by various reactions on external factors in animal tissues with different genetically determined oxygen consumption level or genetically determined adaptation to middle-altitude conditions.
Subject(s)
Adaptation, Physiological/genetics , Gene Expression , Hypoxia , Stress, Psychological , Animals , Hypoxia/etiology , Hypoxia/pathology , Hypoxia/physiopathology , Lung/metabolism , Lung/ultrastructure , Male , Medulla Oblongata/metabolism , Medulla Oblongata/ultrastructure , Myocardium/metabolism , Myocardium/ultrastructure , Organ Specificity , Rats , Rats, Wistar , Restraint, Physical , Stress, Psychological/etiology , Stress, Psychological/pathology , Stress, Psychological/physiopathologyABSTRACT
In experiments on adult white laboratory rats the correlation among external respiration, gas exchange and blood O2 transport under breathing by air and gas mixtures with 40%, 14.5%, 11% and 7% O2 in N2 was investigated. It was demonstrated the narrow structural-functional interrelation in oxygen transport system. The thickness of air-blood barrier (ABB) correlates not only with the external respiration and diffusion capacity of lung, but with parameters, which are not directly connected with the state of lung tissue, such as oxygen content in venous blood, VaO2/VO2 and even with circulation volume. The existence of narrow correlation of ABB thickness and the most of investigated parameters permits to prognosticate the availability of structural disturbances in the presence of external respiration, gas exchange and blood O2 transport changes.
