ABSTRACT
AIM: To evaluate cardiodynamic changes in response to magnetolaser therapy (MLT) and these changes links with lipid shifts in cell membrane. MATERIAL AND METHODS: The study enrolled 50 patients with effort angina (functional class II-III). Of them, 37 patients were exposed to 10-day courses of MLT, 13 patients were exposed to sham procedures. Before the treatment and 3 months after it measurements were made of lipid peroxidation (LPO) products, structure of erythrocytic membrane and cardiodynamic parameters. RESULTS: MLT resulted in a significant reduction of LPO products, stabilization of cell membrane structure and positive shifts in cardiodynamics. Correlation was found between the above parameters. CONCLUSION: Improvement of inotropic, diastolic functions of the myocardium and abatement of cardiac remodeling in coronary heart disease patients in response to MLT is realized primarily due to structural stabilization of cell membrane lipid biolayer.
Subject(s)
Angina Pectoris/radiotherapy , Electromagnetic Fields , Erythrocyte Membrane/radiation effects , Low-Level Light Therapy , Ventricular Function, Left/radiation effects , Angina Pectoris/diagnostic imaging , Angina Pectoris/physiopathology , Blood Pressure/physiology , Blood Pressure/radiation effects , Echocardiography, Doppler , Erythrocyte Membrane/metabolism , Humans , Lipid Peroxidation/radiation effects , Low-Level Light Therapy/methods , Male , Middle Aged , Phospholipids/metabolism , Vascular Resistance/physiology , Vascular Resistance/radiation effects , Ventricular Function, Left/physiologyABSTRACT
50 patients with postinfarction cardiosclerosis and angina pectoris (functional class I-IV) having left ventricular ejection fraction < 45% entered a comparative cross-over trial of antianginal effectiveness of anaprilin and carvediolol (dilatrend). In 10 patients carvedilol was compared to placebo. Carvedilol is shown to demonstrate higher antianginal activity which is the highest in patients with angina pectoris of low load. The analysis of peripheral vascular resistance and double product attributes antianginal advantages of carvedilol to its more potent effect on cardiac performance due to peripheral vasodilatation.
