ABSTRACT
Describes the development of ideas about the regeneration of neurons from the approval "neurons are not restored" to an avalanche stream of messages on neurogenesis. We analysing literature about four ways of neuron regeneration. 1--neurogenesis; 2--intracellular regeneration; 3--BMDC fusion with Purkinje neurons in transgenic experiment; 4--regional cortical cells fusion. In observed some tactical and methodological problems which appears in researches about regeneration. Describes the reasons about the place of these methods of regeneration in modemrnneuroscience.
Subject(s)
Nerve Regeneration , Neurogenesis , Purkinje Cells/physiology , Pyramidal Cells/physiology , Animals , Humans , Neural Stem Cells/cytology , Neural Stem Cells/physiology , Purkinje Cells/cytology , Pyramidal Cells/cytologyABSTRACT
It was investigated the influence of antiortostatic hipokinesia (ANOC) with different combinations with photothrombosis of prefrontal cortex of rat brain by quantitative measures of passive avoidance reflex and reparative processes on the creation of dikaryons in cortex. Recieved data let to suppose, that ANOC increase ischemic damages and decrease quantity of dikaryons in cortex.
Subject(s)
Avoidance Learning , Brain Ischemia , Cerebral Cortex , Hypokinesia , Animals , Brain Ischemia/metabolism , Brain Ischemia/pathology , Brain Ischemia/physiopathology , Cerebral Cortex/metabolism , Cerebral Cortex/pathology , Cerebral Cortex/physiopathology , Hypokinesia/metabolism , Hypokinesia/pathology , Hypokinesia/physiopathology , Male , RatsABSTRACT
A hemorrhagic stroke model that provides the long-term presence of test materials in the focus has been constructed. A lesion is induced in the motor cerebral cortical region. The lesion location and locomotor dysfunction are reproducible. The presence of platelets in the focus reduces the extent and volume of hemorrhages, increases the number and diameter of newly formed vessels, and attracts a macrophage population not found in the control, which is identified from green granules and perivascular location. Motor function is restored more rapidly than in the control. The impact of microgravity is opposite to that of platelets. There are increases in blood congestion, hemorrhage area and postoperative mortality and a reduction in the population of macrophages with green granules. No motor function recovery was observed during a 7-day follow-up.
