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Monomorphic ventricular tachycardia caused by arsenic trioxide therapy for acute promyelocytic leukaemia.
Ducas, R A; Seftel, M D; Ducas, J; Seifer, C.
J R Coll Physicians Edinb ; 41(2): 117-8, 2011 Jun.
Article in English | MEDLINE | ID: mdl-21677914

ABSTRACT

Arsenic trioxide has become the treatment of choice for patients with acute promyelocytic leukaemia. Cardiovascular toxicity is known to occur with this therapy, in particular heart rhythm disorders due to QT interval prolongation. We present a case of ventricular arrhythmia with no QT prolongation in a patient receiving arsenic trioxide therapy.


Subject(s)
Anti-Arrhythmia Agents/therapeutic use , Antineoplastic Agents/adverse effects , Arsenicals/adverse effects , Oxides/adverse effects , Tachycardia, Ventricular/chemically induced , Tachycardia, Ventricular/drug therapy , Adult , Antineoplastic Agents/therapeutic use , Arsenic Trioxide , Arsenicals/therapeutic use , Electrocardiography , Female , Humans , Leukemia, Promyelocytic, Acute/drug therapy , Magnesium/therapeutic use , Manitoba , Metoprolol/therapeutic use , Oxides/therapeutic use , Potassium/therapeutic use , Tachycardia, Ventricular/diagnosis
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