ABSTRACT
To investigate the effects of focal implantation of expanded polytetrafluoroethylene (e-PTFE) episcleral implants (i.e., explants or exoplants) on surrounding ocular tissues, an experimental and histopathological study was performed. Twenty-seven Fauve de Bourgogne rabbits eyes were implanted for a period of 3-11 months with oval-shaped e-PTFE episcleral implants. A newly formed capsule constantly encased the implants. Affected by the only two severe complications observed, 2 eyes had an endocapsular acute inflammation and could not be included in the study. Finally, 25 eyes were studied histopathologically. Neither intrusion nor extrusion of episcleral implants was observed. Other changes were related to implant characteristics. The inner surface of the capsule was often covered with numerous giant cells attesting to a foreign-body granuloma developed against the irregular outline of the episcleral implants. The porosity of the material was closely related to its surface irregularity, and also allowed its colonization by a fibrovascular and inflammatory tissue mainly in its peripheral layers. Under episcleral implants, sclera was both thinned and invaginated. Expanded PTFE hydrophobia was the other factor that might have suscitated granuloma. These microscopic changes are in contrast with an overall good apparent experimental tolerance to the material. However, additional studies on the long term behavior of this material would be helpful.
Subject(s)
Biocompatible Materials/toxicity , Implants, Experimental , Polytetrafluoroethylene/toxicity , Sclera/pathology , Animals , Conjunctivitis/chemically induced , Conjunctivitis/pathology , Eye/pathology , Granuloma/chemically induced , Granuloma/pathology , Hydrogels , Hyperemia/chemically induced , Hyperemia/pathology , Materials Testing , Porosity , Rabbits , SiliconesSubject(s)
Myopia/complications , Retinal Detachment/therapy , Retinal Hemorrhage/therapy , Retinal Neovascularization/therapy , Adult , Female , Humans , Retinal Detachment/diagnosis , Retinal Detachment/etiology , Retinal Hemorrhage/diagnosis , Retinal Hemorrhage/etiology , Retinal Neovascularization/diagnosis , Retinal Neovascularization/etiologyABSTRACT
A randomized double-blind trial was conducted in 143 out-patients with allergic conjunctivitis (281 eyes). Active sodium cromoglycate collyre was compared with placebo in parallel groups over a four-week period. Highly significant advantage for active drug was demonstrated for subjective and objective symptoms as well as for overall assessment by patients and physicians. Results were compared with international data concerning this well-known anti-allergic compound.
Subject(s)
Conjunctivitis/drug therapy , Cromolyn Sodium/therapeutic use , Hypersensitivity/drug therapy , Adult , Child , Clinical Trials as Topic , Cromolyn Sodium/administration & dosage , Double-Blind Method , Humans , Ophthalmic Solutions , Random AllocationABSTRACT
We must consider: -- Superficial ocular myiasis affecting the lacrymal cul-de-sac and ducts and caused by oestridae larvae growing on conjunctiva or lacrymal ducts. -- Deep ocular myiasis affecting either the eyelids or the ocular globe and due to larvae pertaining to several families of flies and requiring an anaerobic phase in their development. This type of myiasis must be separated in two groups according to their localization in the camera anterior or in the camera posterior. Sometimes larvae are very, numerous and demonstrate a high potential of spreading and a phagedena. Surgical treatments are indicated.
