Subject(s)
Flavin Mononucleotide/therapeutic use , Inosine Diphosphate/therapeutic use , Myasthenia Gravis/drug therapy , Niacinamide/therapeutic use , Ozone/therapeutic use , Succinates/therapeutic use , Adult , Aged , Combined Modality Therapy , Drug Combinations , Female , Humans , Male , Middle Aged , Treatment Outcome , Young AdultABSTRACT
Morphological characteristics and trace and macroelement composition of blood cells flowing out of ischemic lower limb before, during and after reconstructive surgeries under different type of anesthesia. A total of 102 male patients aged 45 to 60 years with atherosclerotic occlusions of the arteries of the femoral-popliteal zone were included into the study. According to anesthesia type all the patients were divided into 3 groups: group 1 consisted of 34 patients operated under spinal anesthesia, 37 patients of group 2 underwent surgery under combined anesthesia (spinal anesthesia with intravenous sedation), 31 patients of group 3 - under total intravenous anesthesia with myoplegia and artificial pulmonary ventilation. All the blood examinations were carried out with scanning electron microscope XL-30 ("Philips") and X-ray spectrum microanalyzer Edax ( "Edax International", USA). It is demonstrated that in spinal and combined anesthesia morphological characteristics of blood cells normalized due to optimization of intraerythrocytic and intrathrombocytic electrolytic homeostasis unlike total intravenous anesthesia, when intracellular imbalance of trace and macroelements progresses and ultrastructural cellular alterations persist.
Subject(s)
Atherosclerosis/surgery , Blood Cells/metabolism , Blood Cells/ultrastructure , Electrolytes/blood , Ischemia/surgery , Leg/blood supply , Trace Elements/blood , Anesthesia, Intravenous , Anesthesia, Spinal , Conscious Sedation , Electron Probe Microanalysis , Homeostasis , Humans , Male , Microscopy, Electron, Scanning , Middle Aged , PhotographyABSTRACT
Oxygen transport, its metabolic maintenance and immune status were studied in 17 patients with congenital valvular heart disease (CVD) having compensated (n = 8, group 1) and decompensated (n = 9, group 2) defects of hemodynamics. CVD patients with decompensated central hemodynamics and progressing hypoxia had impaired compensatory rearrangement of oxygen transport system. Accumulation of intracellular lactate, low activity of basic energetic cycles of blood cells most evident in decompensated CVD was observed in both the groups. In conditions of severe energy-structural deficiency and impaired function of oxygen transport systems, CVD patients develop secondary immune deficiency presenting with depression of basic immunoregulatory subpopulations of T- and B- cellular immunity (CD2, CD3, CD4, CD5, CD8, CD16, CD22).
