[Adhesion molecules LFA-1(CD-11a), Mac-1(CD-11b) of t-lymphocytes in bronchoalveolar lavage fluid and blood in patients with chronic respiratory tract disease]. / Czasteczki adhezyjne LFA-1(CD11a), Mac-1(CD11b), ICAM-1(CD54) limfocytów T pochodzacych z plukania oskrzelowo-pecherzykowego i krwi u chorych na przewlekle choroby ukladu oddechowego.

Adhesion molecules play an important role in inflammatory processes and influence on recruitment of effector cells. The aim of our study was to assess the percentage of T-lymphocytes expressing LFA-1, Mac-1 and ICAM-1 in bronchoalveolar fluid (BALF) and blood of patients with sarcoidosis, atopic bronchial asthma and chronic bronchitis. The reference group consisted of patients with haemoptysis or suspected of having bronchial carcinoma. Expression of adhesion molecules was revealed by /APAAP/ alkaline phosphatase anti alkaline phosphatase method. The highest percentage of lymphocytes expressing all adhesions molecules in BALF and blood was observed in patients with chronic bronchitis. Reductions of T-cells in BALF of patients with bronchial asthma and sarcoidosis may reflect of their direct binding in inflammatory sites. This studies confirm the involvement of adhesion molecules in maintenance of chronic inflammatory processes in the respiratory tract.

[Serological screening examinations of atypical pathogens (Mycoplasma pneumoniae, Chlamydia pneumoniae) in respiratory tract infection]. / Serologiczne badanie przesiewowe atypowych czynników (Mycoplasma pneumoniae, Chlamydia pneumoniae) w zakazeniach ukladu oddechowego.

Lower respiratory tract infections are a heterogeneous group of disorders induced by plenty of pathogens. Atypical bacteria play an important role in the respiratory tract pathology. In our study 90 patients with acute infection of the respiratory tract were examined in serological screening test for Mycoplasma pneumonia and Chlamydia pneumoniae. It was confirmed that in 21 patients with community acquired pneumonia Mycoplasma pneumonia antibodies were detected in 38% and Chlamydia pneumoniae in 10%. In our opinion this screening serological tests are useful for early diagnosis of atypical bacterial infections of the respiratory tract.

[The treatment of a fracture of proximal end of the femur in own material]. / Leczenie zlaman blizszego konca kosci udowej w materiale wlasnym.

Results of treatment for fracture of proximal end of the femur in 263 patients (86 males and 177 females) aged between 7 and 104 years were analyzed. Ninety percent of the patients were older than 60 years. Mean follow-up was 4.6 years (range 1 to 9 years). Immediate Austin-Moore hip hemiarthroplasty in the elderly and screw fixation in younger patients rendered best results in the femoral neck fractures. Ender nailing in the elderly and angular plating or skeletal traction in the young proved most successful in trochanteric fractures.

[Local treatment with tumor necrosis factor alpha in a patient with lung cancer]. / Miejscowe leczenie czynnikiem martwicy nowotworów-alpha u chorej z guzem pluca.

Tumor Necrosis Factor alfa (TNFa) is a cytokine with cytolytic and cytotoxic properties. First clinical trials in which TNF was administered parenterally date back to early 70-ties. Soon it was noticed that when administered strictly to the tumor mass TNF exhibits high anti-tumor efficacy, exemplified by total or at least substantial regression of the tumor mass while producing minor and controllable symptoms. In this paper the case of local administration of the recombinant TNFa directly into the tumor mass constricting the bronchus was presented.

[Use of calcitonin in treatment of bone pain]. / Zastosowanie kalcytoniny w leczeniu bólu kostnego.

The studies were carried out assessing the effect of calcitonin in the treatment of bone pain. In the years 1990-1992 43 patients were studied. Pain intensity scale was used with evaluation by doctor and patient.