Subject(s)
Head and Neck Neoplasms/diagnosis , Head and Neck Neoplasms/surgery , Lipoma/diagnosis , Lipoma/surgery , Adult , Humans , MaleABSTRACT
Ewing sarcoma/primitive neuroectodermal tumor is classically a tumor of the soft tissue or bone in children and young adults, but several cases have been described in patients of all ages. Within the last decade, the clinicopathologic spectrum of Ewing sarcoma/primitive neuroectodermal tumor has been markedly expanded by recognition that the tumor may also have a visceral origin. We describe a case of primitive neuroectodermal tumor arising in the stomach of a 66-year-old woman. The neoplasm was excised using a radical surgical procedure. Microscopically, the tumor was made up of solid nests and sheets of round cells. Immunohistochemically, the tumor cells showed immunoreactivity for CD99, S100, neuron-specific enolase, and vimentin. A multiplex real-time polymerase chain reaction assay detected an EWS-ERG fusion. To our knowledge, this is the first description of a primitive neuroectodermal tumor arising in the stomach.
Subject(s)
Neuroectodermal Tumors, Primitive/diagnosis , Stomach Neoplasms/diagnosis , Aged , Female , HumansABSTRACT
We describe the clinicopathological features of a peripheral ameloblastic fibrosarcoma (PAFS) diagnosed in a 89-years-old man with a past history of recurrent peripheral ameloblastoma. Like other peripheral odontogenic tumors, PAFS shows histological features comparable to those of the central intraosseous form, with (fibro)sarcomatous proliferation associated to benign-appearing ameloblastomatous areas. The differential diagnosis must be made with a low-grade spindle ameloblastic carcinoma and with a collision tumor (a non odontogenic sarcoma associated with a recurrent ameloblastoma). Almost any odontogenic tumor has been observed in the peripheral soft tissues, but our case seems to be, to our best knowledge, the first case of PAFS reported in the literature. This fact can only reflect the rarity of its central counterpart. A particular feature is the old age of our patient (ameloblastic fibrosarcoma usually occurs in adolescent or young adult). Another particular feature is that this PAFS appeared in the contiguity of a recurrent peripheral ameloblastoma. As proposed by many authors, this finding suggests that peripheral odontogenic tumors should require a long-term follow-up and, maybe, a more aggressive initial surgical management.
