1.
Folia Microbiol (Praha)
; 55(5): 418-21, 2010 Sep.
Article
in English
| MEDLINE
| ID: mdl-20941574
ABSTRACT
The in-vitro biological activity of N-benzylsalicylthioamides against 8 bacterial strains was determined by broth microdilution method; results were compared with those obtained with neomycin, penicillin G, ciprofloxacin and penicillin V. The compounds showed moderate to high activity against G(+) bacteria; especially compounds 4, 6, 13, 16-21 and 24 exhibited comparable or higher activity than reference drugs. The antibacterial activity was analyzed by quantitative structure-activity relationship (QSAR). The antibacterial activity increased with lipophilicity, with the presence of halogens and with increasing value of Hammet substituent constant σ.
Subject(s)
Anti-Bacterial Agents/pharmacology , Gram-Negative Bacteria/drug effects , Gram-Positive Cocci/drug effects , Thioamides/pharmacology , Anti-Bacterial Agents/chemistry , Humans , Microbial Sensitivity Tests , Structure-Activity Relationship , Thioamides/chemistry
2.
Z Orthop Ihre Grenzgeb
; 110(3): 325-30, 1972 Jun.
Article
in German
| MEDLINE
| ID: mdl-4263215