1.
Ross Fiziol Zh Im I M Sechenova
; 90(5): 638-44, 2004 May.
Article
in Russian
| MEDLINE
| ID: mdl-15341088
ABSTRACT
The influence of chronic administration of nicotine diluted in the drinking water on the parameters of systemic inflammation and autoimmune processes in rats (August line) with adjuvant-induced arthritis, were studied. The experiments have shown that nicotine acts as an antiphlogistic means (the amount of C-reactive protein rises in the blood) and activates autoimmune processes: induction of rheumatic factor, of autoantibodies to serotonin, and glial fibrillar acid protein. It was supposed that nicotine has a potential impact on immunocompetent cells.