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J Pharm Biomed Anal ; 14(4): 451-6, 1996 Feb.
Article in English | MEDLINE | ID: mdl-8729644

ABSTRACT

The development of a reversed-phase liquid chromatographic method, using a mobile phase containing a mixture of anion and cation ion-pairing agents and a base-deactivated octyldecylsilyl column as stationary phase, is described for the control of all known impurities in (Z)-chlorprothixene hydrochloride (bulk drug). Validation of the method showed it to be reproducible, selective for both (Z) chlorprothixene hydrochloride and its E-isomer, accurate and linear over the concentration range of analysis with a limit of detection of 0.3 microgram ml-1.


Subject(s)
Antipsychotic Agents/isolation & purification , Chlorprothixene/isolation & purification , Chromatography, Liquid/methods , Antipsychotic Agents/chemistry , Chlorprothixene/chemistry , Molecular Conformation , Reproducibility of Results
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