ABSTRACT
In M. bovis-infected rabbits, antigen-binding lymphocytes (ABL) of tuberculin specificity were detected within 7-105 days after inoculation. Due to etiotropic chemotherapy, ABL disappeared 31-45 days following inoculation. At the trial's end, the seeding rate and morphological changes in the organs of M. bovis-infected correlated with the content of ABL 105 days after inoculation. The early disappearance of ABL in the rats is regarded as an index of the efficiency of treatment for tuberculosis.
Subject(s)
Mycobacterium bovis/immunology , T-Lymphocytes/immunology , Tuberculin/immunology , Tuberculosis/immunology , Tuberculosis/therapy , Animals , Antigen Presentation , Rabbits , T-Lymphocyte Subsets/immunologyABSTRACT
The efficiency of diagnosis of active tuberculosis was evaluated from detection of tuberculin-receptor lymphocytes [antigen-binding lymphocytes (ABL)] by the indirect rossette-formation test with the red blood cell reagent designed. Sixty two patients with tuberculosis (of them 10 patients with extrapulmonary tuberculosis), 10 with lobular pneumonia, and 27 healthy individuals cal were examined. Positive results of fluography, smear microscopy, bacteriological study, leukocytic migration inhibition test, and test for ABL were obtained in 84, 40, 50, 39, and 100%, respectively. The controls had negative tests. Thus, ABL detection was the method of choice in tuberculosis diagnosis.