ABSTRACT
We prospectively examined the effectiveness of diagnostic tests for anaplasmosis using patients with suspected diagnoses in France. PCR (sensitivity 0.74, specificity 1) was the best-suited test. Serology had a lower specificity but higher sensitivity when testing acute and convalescent samples. PCR and serology should be used in combination for anaplasmosis diagnosis.
Subject(s)
Anaplasma phagocytophilum/classification , Anaplasma phagocytophilum/genetics , Anaplasmosis/diagnosis , Anaplasmosis/microbiology , Anaplasmosis/epidemiology , Biopsy , France/epidemiology , Humans , Polymerase Chain Reaction , Prospective Studies , Reproducibility of Results , Sensitivity and Specificity , Serologic TestsABSTRACT
Diabetes mellitus is, in most patients, a multi-metabolic condition disease under fixed standardized conditions. We develop here the advantages of a chronobiological approach, exploring nycthemeral variations in blood pressure, variations in insulin resistance, postprandial changes in blood glucose and postabsorptive variations in blood lipids. Such information can help improve our understanding of the disease, better identify risk and prognosis, and enlighten therapeutic options.
