[Cystic lymphangioma of the supraclavicular and right axillary fossae]. / Naczyniak limfatyczny torbielowaty dolu nadobojczykowego i pachowego prawego.

Five years ago, in a 34-year-old female patient a tumour developed in the right supraclavicular fossa which gradually increased in size. A few months ago she had noticed also a tumour in the axillary fossa on the same side. On physical examination, USG, and contrast X-ray it was found that it was a cyst of hour-glass shape (narrowing of retro-clavicular). The cyst was removed totally. Histological examination: cystic lymphangioma (hygroma). The aetiology, diagnosis, and treatment of this type of tumours are discussed.

[Rejection of allogeneic bone marrow transplant. Case report]. / Odrzucenie allogenicznego przeszczepu szpiku. Opis przypadku.

In a patient aged 22 years with acute myeloblastic leukaemia during complete remission an allogenic transplant of bone marrow identical in the HLA antigen range was rejected despite administration before transplantation of a full marrow-ablating dose of busulphan (16 mg/kg) and severe graft-versus-host disease. Graft rejection manifested itself as disappearance of its haemopoietic function which was confirmed during the life and on autopsy. The case deserves attention in view of the rarity of HLA-identical marrow graft rejections in patients treated for leukaemias.

Morphology and function of liver after intravenous and intraportal injections of the immunomodulating agent Propionibacterium granulosum.

An immunomodulator, cell walls from Propionibacterium granulosum strain KP-45 (PG), has been applied in rabbits to test its influence on morphology and function of liver cells. For investigation of distribution in internal organs, the PG preparation was 51Cr-labelled and injected i.v. into mice. Functional liver tests were performed in rabbits injected intravenously or intraportally with PG. Morphologic studies (light and electron microscopy) of liver sections were performed in mice and rats injected intravenously with PG, 1-60 d prior to liver examination. Intravenous or intraportal application of PG did not cause detectable clinical symptoms during the whole observation period (1-60 d). During the first 3-7 d, elevation of serum globulins and transaminases (SGOT, SGPT) were noted with reappearance of normal values after 14-20 d. 131I-labelled Bengal Rose injected into PG-treated rabbits was trapped mostly in the spleen, and to a smaller extent in liver, where radioactivity was significantly lower than in saline-injected control animals. 51Cr-labelled PG injected i.v. into mice were after 60-90 min localized preferentially in lungs and liver, where the radioactivity was much higher than in the spleen. Morphological studies revealed that 6 h following i.v. injection of PG, there appeared partial clearing of the hepatocyte cytoplasm and lowering of their basophilic content with enhancement of pinocytic activity of the hepatocytes. This was accompanied by enlargement of RES cells in liver with enhanced intracellular digestion, higher number of lysosomes and appearance of phagocytic vacuoles.(ABSTRACT TRUNCATED AT 250 WORDS)

[Local immunomodulation in advanced Crohn disease with a cell-wall preparation of Propionibacterium granulosum KP-45]. / Lokale Immunmodulation bei fortgeschrittenem Morbus Crohn mit einem Zellwandpräparat von Propionibacterium granulosum KP-45.

Four patients aged 30-34 years with Crohn's disease in and advanced stage, having lasted 2 or 3 years, were treated by several injections of 10mg lyophilized cell wall material of P. granulosum strain KP-45 locally into the lesion. In all 4 cases a preceding conventional therapy with Salazopyrine and Prednisone or surgery had been unsuccessful. This local immunomodulatory treatment led to decisive improvement of the disease in all 4 cases, in 3 cases inflammatory symptoms disappeared completely. For this reason a local immunomodulation with P. granulosum KP-45 is recommended as an additional therapeutic procedure in patients who are otherwise resistant to therapy.