The effect of ketanserin in essential hypertension.

Ketanserin, a 5HT2-receptor blocking drug was given to 17 patients with essential hypertension. Satisfactory control was achieved in 13 patients. Control was not as satisfactory when given once daily. There was no rebound effect when the drug was ceased. Side-effects were few. Ketanserin was a satisfactory drug to reduce blood pressure in patients with moderate hypertension.

Patterns of serum LH and FSH in response to 4-hour infusions of luteinizing hormone releasing hormone in normal women during menstrual cycle, on oral contraceptives, and in postmenopausal state.

PIP: Patterns of serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) in response to 4-hour infusions (1 mcg/min) of LH-releasing hormone in 16 normal women during the menstrual cycle, in 4 women on oral contraceptives (OCs), and in 3 postmenopausal women were investigated. A biphasic response of LH was observed in the follicular and luteal phases, with the response much larger in the latter (p .001). The largest LH response was observed during the periovulatory phase (p .001). Women on combined OCs studied between Cycle Days 11-14 showed a biphasic response intermediate in magnitude (p .05) between follicular and luteal phases with some blunting of the initial phase of secretion. FSH response was not clearly biphasic but was greatest in the periovulatory phase (p .001), intermediate in the luteal phase (p .01), and least in the follicular phase. In postmenopausal women, total output of LH was similar to the luteal phase and the output of FSH was equivalent to that at midcycle. These data support the concept that the biphasic response to LH to the prolonged infusion is present in women and that its magnitude and characteristics may be modulated by estradiol and progesterone levels.^ieng

Serum LH and FSH response in four-hour infusions of luteinizing hormone-releasing hormone in normal men, Sertoli cell only syndrome, and Klinefelter's syndrome.

Constant intravenous infusion of 1 mug/min of luteinizing hormone-releasing hormone (LHRH) for 4 hours into normal men produced a biphasic pattern of LH secretion. The initial LH peak occurred 15-45 minutes after the commencement of the infusion, following which LH levels plateaued or declined, subsequently rising as the infusion continued. No biphasic pattern of secretion could be identified for FSH. During the infusion, no consistent testosterone rise could be identified despite significant elevation of LH levels. Similar infusions of LHRH in men with Sertoli cell only syndrome produced exaggerated responses in terms of both LH and FSH. In contrast, a single intravenous bolus of 100 mug/ LHRH produced an exaggerated response in only one of the 3 men studied, suggesting that the prolonged infusion may be a more discerning dynamic test. Four-hour infusions of LHRH in men with untreated Klinefelter's syndrome produced exaggerated responses for both LH and FSH. After 6 weeks of treatment with long-acting testosterone esters administered weekly (250 mg), the exaggerated responses for both FSH and LH were decreased. For LH, the decrease principally affected the initial phase of LH release, and the pattern obtained resembled more closely the biphasic pattern seen in normal men.