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Indoline derivatives as 5-HT(2C) receptor agonists.

Bentley, J M; Adams, D R; Bebbington, D; Benwell, K R; Bickerdike, M J; Davidson, J E P; Dawson, C E; Dourish, C T; Duncton, M A J; Gaur, S; George, A R; Giles, P R; Hamlyn, R J; Kennett, G A; Knight, A R; Malcolm, C S; Mansell, H L; Misra, A; Monck, N J T; Pratt, R M; Quirk, K; Roffey, J R A; Vickers, S P; Cliffe, I A.

Bioorg Med Chem Lett ; 14(9): 2367-70, 2004 May 03.

Article in English | MEDLINE | ID: mdl-15081042

ABSTRACT

A series of 1-(1-indolinyl)-2-propylamines was synthesised and evaluated as 5-HT(2C) receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are described. The functional efficacy and radioligand binding data for all of the compounds at 5-HT(2) receptor subtypes are reported. A number of compounds were found to reduce food intake in rats after oral administration.

Subject(s)

Anti-Obesity Agents/pharmacology , Indoles/pharmacology , Serotonin 5-HT2 Receptor Agonists , Serotonin Receptor Agonists/pharmacology , Animals , Anti-Obesity Agents/chemistry , Indoles/chemistry , Rats

ABSTRACT

Subject(s)

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