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J Natl Cancer Inst ; 54(2): 507-13, 1975 Feb.
Article in English | MEDLINE | ID: mdl-46277

ABSTRACT

Argyrophilic carcinoids were found in 2 Syrian hamsters (Mesocricetus auratus). A solitary neoplasm was located in the glandular stomach of a 25.5-month-old animal that had ingested for 12 months laboratory chow to which arecoline and calcium hydroxide [Ca(OH)2] had been added. In the other hamster, a primary carcinoid of the pancreas had metastasized to the mesenteric lymph nodes and liver; this was in a 22-month-old animal that had ingested for 16 months chow containing added snuff and Ca(OH)I. It is not known whether the carcinoids were spontaneous or induced by the treatment. Argyrophilic carcinoids have previously been reported in only one other rodent species.


Subject(s)
Carcinoid Tumor/pathology , Pancreatic Neoplasms/pathology , Stomach Neoplasms/pathology , Animals , Arecoline/toxicity , Calcium Hydroxide/toxicity , Carcinoid Tumor/etiology , Cricetinae , Diet , Liver Neoplasms , Lymphatic Metastasis , Neoplasm Metastasis , Neoplasms, Experimental/etiology , Neoplasms, Experimental/pathology , Plants, Toxic , Silver , Staining and Labeling , Tobacco, Smokeless
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