1.
AIDS
; 27(8): 1353-6, 2013 May 15.
Article
in English
| MEDLINE
| ID: mdl-23462216
ABSTRACT
We examined the relationship between plasma adipokine concentrations and ultrasound measures of vascular health in 100 HIV-infected adults on antiretroviral therapy. Leptin was positively correlated with flow-mediated dilation of the brachial artery and negatively with carotid intima-media thickness. These relationships were independent of traditional risk factors and trunk fat in women but not men. Neither adiponectin nor resistin was associated with either measure of vascular health.
Subject(s)
Adipokines/blood , Carotid Artery Diseases/diagnostic imaging , HIV Infections/blood , Obesity/blood , Absorptiometry, Photon , Adult , Anti-HIV Agents/therapeutic use , Body Mass Index , Brachial Artery/diagnostic imaging , Carotid Arteries/diagnostic imaging , Enzyme-Linked Immunosorbent Assay , Female , HIV Infections/drug therapy , Humans , Leptin/blood , Male , Middle Aged , Resistin/blood , Risk Factors , Ultrasonography
2.
Bioorg Med Chem Lett
; 21(6): 1741-3, 2011 Mar 15.
Article
in English
| MEDLINE
| ID: mdl-21316228
ABSTRACT
A series of N-(pyrimidin-4-yl)-phenylalanine VLA-4 antagonists is described. Optimization of substituents at the 2 and 5 positions of the pyrimidine ring gave 14, a very potent VLA-4 inhibitor which is orally active in a sheep asthma model.
