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1.
Brain Struct Funct ; 218(1): 131-49, 2013 Jan.
Article in English | MEDLINE | ID: mdl-22318412

ABSTRACT

We have studied the distribution of alpha-neo-endorphin- or neurokinin B-immunoreactive fibres and cell bodies in the adult human brainstem with no prior history of neurological or psychiatric disease. A low density of alpha-neo-endorphin-immunoreactive cell bodies was only observed in the medullary central gray matter and in the spinal trigeminal nucleus (gelatinosa part). Alpha-neo-endorphin-immunoreactive fibres were moderately distributed throughout the human brainstem. A high density of alpha-neo-endorphin-immunoreactive fibres was found only in the solitary nucleus (caudal part), in the spinal trigeminal nucleus (caudal part), and in the gelatinosa part of the latter nucleus. Neurokinin B-immunoreactive cell bodies (low density) were found in the periventricular central gray matter, the reticular formation of the pons and in the superior colliculus. The distribution of the neurokinin-immunoreactive fibres was restricted. In general, for both neuropeptides the density of the immunoreactive fibres was low. In the human brainstem, the proenkephalin system was more widely distributed than the prodynorphin system, and the preprotachykinin A system (neurokinin A) was more widely distributed than the preprotachykinin B system (neurokinin B).


Subject(s)
Brain Stem/chemistry , Endorphins/analysis , Immunohistochemistry , Nerve Fibers/chemistry , Neurokinin B/analysis , Protein Precursors/analysis , Aged , Aged, 80 and over , Autopsy , Biomarkers/analysis , Brain Stem/cytology , Female , Humans , Male
2.
Biomédica (Bogotá) ; 19(3): 207-13, sept. 1999. ilus
Article in Spanish | LILACS | ID: lil-252643

ABSTRACT

Se entubó el nervio ciático de ratas, luego de un corte transverso, utilizando una cámara de silicona de 14 mm de largo que tenía dos ventanas de 8mm de largo cubiertas con malla de 10 o 60 µm. Después de 6 meses, los animales se perfundieron con una mezcla de glutaraldehído y paraformaldehído, y se evaluó el aspecto microscópico de los nervios regenerados en dos niveles dentro de la cámara (3 mm y nivel medio) y 5 mm distal a ésta. Se contó el número de fibras mielínicas presentes en cada nivel y tratamiento, y se realizó una comparación entre ellos. Se encontro una importante desorganización del endoneurio a nivel medio de la cámara. Distalmente, los conteos de fibras mielínicas fueron muy bajos. No se observaron diferencias significativas entre los grupos con mallas de 10 y 60 µm. En conclusión, la presencia de poros de 10 o 60 µm no impide la entrada masiva de fibroblastos a la cámara, llevando a una marcada desorganización del nervio regenerado


Subject(s)
Rats , Diffusion Chambers, Culture , In Vitro Techniques , Nerve Regeneration
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