ABSTRACT
Se presenta el caso de una paciente de 73 años de edad que, a los 30 años aproximadamente, comenzó a quejarse de dolor al caminar, localizando la molestia a nivel de las regiones aquilianas, con subsecuente aumento de volumen; al paso del tiempo, estas molestias la obligaron a efectuar consulta médica. Los análisis de laboratorio mostraron severa dislipidemia mixta. Al lado de información de significativa declinación cognitiva, provista por familiares (vgr., (i.e., olvidos frecuentes, desorientación, atención disminuida, concentración pobre), hubo evidencia de ánimo fluctuante, labilidad emocional, crisis ansiosas evolucionando hacia ataques de pánico. El test minicognitivo de Folstein, mostró severo estado demencial y en el examen neurológico se constataron ataxia cerebelosa y signos de piramidalismo parcial. El examen oftalmológico puso en evidencia xantelasmas, cataratas y un denso arco senil. El estudio del cerebro con resonancia magnética (RM) mostró el daño encefálico y signos sugestivos de depósitos del colastenol en el SNC. La presencia de xantomas , los hallazgos oftalmológicos, la demencia definidamente progresiva y la ataxia cerebelosa fueron hallazgos clÃnicos que permitieron establecer el diagnóstico de xantomatosis cerebrotendinosa.
The case of a 73 years-old woman that, since approximately the age of 30 years started to complain of pain when walking, is presented. The symptom was mainly located in the acchillean regions which, as time advanced, showed gradual volume increase and, finally, forced her to seek medical evaluation. Accompanying relatives reported a several yearsâ history of gradually increasing cognitive difficulties (i.e., forgetfulness, disorientation, poor attention and concentration), fluctuating mood (from periods of good humor switching to sudden episodes of sadness and crying spells), emotional lability and anxiety crises evolving into brief panic attacks. The Mini-cognitive Fenton Test confirmed severe dementia and the neurological evaluation showed cerebellar ataxia and partial pyramidalism. The ophthalmological examination revealed xanthelasmas, cataracts and dense arcus senilis. Xanthomas were detected in the Achillean tendons of both lower extremities. Auxiliary laboratory and densitometric tests demonstrated mixed dyslipidemia and dorsal-lumbar osteoporosis, respectively, and magnetic resonance imaging of the brain (RMC) confirmed SNC damage and suggested deposits of cholestenol, thus confirming the diagnosis of Cerebroitendinous Xanthomatosis.
ABSTRACT
Bovine tuberculosis (bTB) is a chronic infectious disease that affects both domestic animals and wildlife. Veterinary epidemiology studies evaluate bTB using geographic information systems (GIS), which can characterise the spatial and temporal distribution of diseases and identify the geographic areas and animal populations at risk of contracting a disease. The present study used spacetime permutation scan statistic to identify the spatial and temporal distribution of bTB from 2005 to 2010 in the State of Mexico with the goal of creating a similarity model using Mahalanobis Distance to identify areas suitable for bTB occurrence. Three significant clusters were identified using spacetime permutation scan statistic and the similarity model identified several areas with suitable environmental and demographic characteristics. The results demonstrate that the occurrence of bTB in the State of Mexico is not randomly distributed.
Subject(s)
Geographic Information Systems , Tuberculosis, Bovine/epidemiology , Animals , Animals, Wild , Cattle , Mexico/epidemiologyABSTRACT
Glasses from xCuOâ (100-x)[7GeO(2)â 3PbO(2)â 0.05Al(2)O(3)] system where x=0, 1, 5, 10, 20 and 30 mol% CuO were studied by FT-IR, UV-VIS and ESR spectroscopy in order to obtain information about the structural correlations and the relationship between structure and optical properties in these materials. The analyses of these IR spectra reveal that the accommodation of the network with the excess of oxygen ions is possible by the depolymerization of the germanate network in shorter chains, especially ortho- and/or pyrogermanate structural units. UV-VIS absorption spectrum of the sample with x=1% CuO begins with a rising absorption band situated at about 250 nm. This band can be assigned to the GeOGe wrong bonds such as the Ge(+2) centers. Optical study is performed to calculate the refractive index and optical band gap using UV-VIS spectra in the wavelength range 250-1,000 nm. The increase in optical band is explained on the basis of the average bond energy of the system and the number of non-bridging oxygen ions. ESR spectra of CuO substituted samples are characterized by broad peaks probably because of the formation of Cu(+2)-Ge(+2) exchange pairs which are weakly coupled though the oxygen atom.
Subject(s)
Aluminum Oxide/chemistry , Copper/chemistry , Germanium/chemistry , Glass/chemistry , Lead/chemistry , Electron Spin Resonance Spectroscopy , Spectrophotometry, Ultraviolet , Spectroscopy, Fourier Transform InfraredABSTRACT
The aim of this study was to follow the postmortem ethanol production phenomenon under controlled experimental conditions (temperature, time interval) in different tissues. Specimens of blood, liver, skeletal muscle and kidney were taken from 30 corpses and no chemical preservatives were used in the specimens collected. Ethanol concentrations were detected by gas chromatography. All specimens stored at -20 degrees C and 4 degrees C did not show any change in ethanol concentration in an eight-day time interval. At 20 degrees C and 30 degrees C, all tissues, except blood, showed statistically significant ethanol production over the time interval tested. However, blood sample kept at 30 degrees C, showed statistically significant increase in ethanol production on the 2nd and 4th day comparing to the controls. Thus, we can state that postmortem ethanol production occurs in different tissues, and is increased at higher temperatures and, in general, it is in accordance with the course of time.
