Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Clin Exp Immunol ; 181(2): 267-74, 2015 Aug.
Article in English | MEDLINE | ID: mdl-25677249

ABSTRACT

Current UK national standards recommend routine bacteriology surveillance in severe antibody-deficient patients, but less guidance exists on virology screening and viral infections in these patients. In this retrospective audit, we assessed the proportion of positive virology or bacteriology respiratory and stool samples from patients with severe, partial or no immune deficiency during a 2-year period. Medical notes were reviewed to identify symptomatic viral infections and to describe the course of persistent viral infections. During the 2-year period, 31 of 78 (39·7%) severe immune-deficient patients tested had a positive virology result and 89 of 160 (55.6%) had a positive bacteriology result. The most commonly detected pathogens were rhinovirus (12 patients), norovirus (6), Haemophilus influenzae (24), Pseudomonas spp. (22) and Staphylococcus aureus (21). Ninety-seven per cent of positive viral detection samples were from patients who were symptomatic. Low serum immunoglobulin IgA levels were more prevalent in patients with a positive virology sample compared to the total cohort (P = 0·0078). Three patients had persistent norovirus infection with sequential positive isolates for 9, 30 and 16 months. Virology screening of symptomatic antibody-deficient patients may be useful as a guide to anti-microbial treatment. A proportion of these patients may experience persistent viral infections with significant morbidity.


Subject(s)
Antibodies, Bacterial/blood , Antibodies, Viral/blood , Haemophilus Infections/immunology , Immunologic Deficiency Syndromes/immunology , Picornaviridae Infections/immunology , Pseudomonas Infections/immunology , Staphylococcal Infections/immunology , Bronchoalveolar Lavage Fluid/microbiology , Bronchoalveolar Lavage Fluid/virology , Feces/microbiology , Feces/virology , Haemophilus Infections/microbiology , Haemophilus Infections/pathology , Haemophilus influenzae/immunology , Haemophilus influenzae/isolation & purification , Humans , Immunoglobulin A/blood , Immunologic Deficiency Syndromes/microbiology , Immunologic Deficiency Syndromes/pathology , Immunologic Deficiency Syndromes/virology , Picornaviridae Infections/pathology , Picornaviridae Infections/virology , Pseudomonas/immunology , Pseudomonas/isolation & purification , Pseudomonas Infections/microbiology , Pseudomonas Infections/pathology , Retrospective Studies , Rhinovirus/immunology , Rhinovirus/isolation & purification , Staphylococcal Infections/microbiology , Staphylococcal Infections/pathology , Staphylococcus aureus/immunology , Staphylococcus aureus/isolation & purification
SELECTION OF CITATIONS
SEARCH DETAIL
...