Influence of partial suckling of crossbred dairy cows on milk offtake and calf growth in the Ethiopian highlands.

The effects of implementing a restricted suckling regime with crossbred dairy cows have been examined in the Ethiopian highlands. Calves were allowed to suckle their dams for two minutes before each milking until weaning and this system was compared with the common practice of rearing by bucket feeding. Restricted suckling significantly increased calf growth rate to weaning, from 0.31 to 0.53 kg/d (P less than 0.01). No differences in calf growth post-weaning occurred, so that the 20 kg difference in liveweight that had been achieved by the restricted suckled calves by the time of weaning persisted until the calves were nine months old, when observations ceased. Total milk offtake was not significantly affected by treatment, although that obtained from the partially-suckled animals over their whole lactation exceeded that from the other treatment by 15%. Partial suckling delayed return to oestrus post partum but this was offset to some degree by fewer services per conception, hence calving interval was not significantly increased. Voluntary feed consumption was similarly unaffected and it is concluded that restricted suckling offers tangible advantages for adoption by smallholders using crossbred cows in dairy production systems.

Dual-action cephalosporins: cephalosporin 3'-quaternary ammonium quinolones.

When cephalosporins exert their biological activity by reacting with bacterial enzymes, opening of the beta-lactam ring can lead to expulsion of the 3'-substituent. A series of cephalosporins was prepared in which antibacterial quinolones were linked to the 3'-position through a quaternary nitrogen. Like the 3'-ester-linked dual-action cephalosporins reported earlier, these compounds demonstrated a broad spectrum of antibacterial activity derived from cephalosporin-like and quinolone-like components, suggesting a dual mode of action.

In vitro activity of Ro 19-5247 (T-2525) and interpretive criteria for disk diffusion susceptibility testing.

The activity of Ro 19-5247 (the active metabolite of the oral cephalosporin Ro 19-5248 [T-2588]) was compared with that of five orally active agents against a total of 331 bacterial strains. Ro 19-5247 was more active in vitro than amoxicillin, amoxicillin-clavulanate, cefaclor, cefuroxime, and cephalexin against members of the family Enterobacteriaceae. Amoxicillin-clavulanate and amoxicillin overall were more active than the other four agents against staphylococci. Ro 19-5247, amoxicillin-clavulanate, amoxicillin, and cefuroxime were equally active against nonenterococcal streptococci and more active than cefaclor and cephalexin. All six agents showed little or no activity against nonfermentative gram-negative bacteria. Against Streptococcus (Enterococcus) faecalis, only amoxicillin and amoxicillin-clavulanate were active. The interpretive criteria for in vitro susceptibility testing with 10- and 30-micrograms Ro 19-5247 disks were established by regression analysis to correlate the inhibitory zone sizes and MICs for the bacterial isolates. The suggested tentative zone size breakpoints for the 10-micrograms disk are as follows: susceptible, greater than or equal to 22 mm (MIC, less than or equal to 2 micrograms/ml); moderately susceptible, 20 to 21 mm (MIC, 4 micrograms/ml); and resistant, less than or equal to 19 mm (MIC, greater than or equal to 8 micrograms/ml).