Evaluating the impact of pre-hospital trauma team activation criteria.

BACKGROUND: Little evidence exists studying the benefits of pre-hospital trauma team activation. Our study measured the impact of pre-hospital trauma team activation on 24-h survival. Our secondary objectives assessed the effects of pre-hospital trauma team activation on time to emergency procedure, computed tomography, blood transfusion, and critical administration threshold, as well as emergency department length of stay. METHODS: We conducted a 40-month health records review on all trauma team activations at The Ottawa Hospital, a Level 1 Trauma Center. Outcomes were compared between pre-hospital and in-hospital trauma team activations. We used logistic and linear regression models to assess outcomes, while controlling for injury severity score, age, systolic blood pressure, and anti-coagulation use. A P value < 0.05 was considered statistically significant. A sensitivity analysis was also used to validate the primary outcome results. RESULTS: Of the 1013 trauma team activations occurring during the study period, 762 patients were included. The mean age (41.3 vs. 43.8) and percentage of males (79.4% vs. 77.5%) for pre-hospital activations were similar to their counterparts. Pre-hospital activations did not have a statistically significant effect on 24-h mortality (14.4% vs. 4.5%; P = 0.30). However, pre-hospital activations did demonstrate a statistically significant reduction in time (minutes) to emergency procedure (18.0 vs. 27.0; P < 0.001), computed tomography (37.0 vs 42.0; P = 0.009), and blood transfusion (14.0 vs. 28.0; P < 0.001), as well as emergency department length of stay (101.0 vs. 171.0; P < 0.001). CONCLUSION: When controlling for key covariates, pre-hospital trauma team activation did not have a significant effect on 24-h mortality, but did result in a significant reduction in time to emergency procedure, computed tomography, and blood transfusion, as well as emergency department length of stay. Our study demonstrates that pre-hospital trauma team activation can expedite patient intervention and disposition.

RéSUMé: CONTEXTE: Il existe peu de données sur les avantages de l'activation de l'équipe de traumatologie préhospitalière. Notre étude a mesuré l'impact de l'activation de l'équipe de traumatologie pré-hospitalière sur la survie à 24 heures. Nos objectifs secondaires ont évalué les effets de l'activation de l'équipe de traumatologie préhospitalière sur le délai de la procédure d'urgence, de la tomodensitométrie, de la transfusion sanguine et du seuil d'administration critique, ainsi que sur la durée du séjour dans les services d'urgence. MéTHODES: Nous avons procédé à un examen des dossiers médicaux sur 40 mois pour toutes les activations de l'équipe de traumatologie à l'Hôpital d'Ottawa, un centre de traumatologie de niveau 1. Les résultats ont été comparés entre les activations des équipes de traumatologie pré-hospitalières et intra-hospitalières. Nous avons utilisé des modèles de régression logistique et linéaire pour évaluer les résultats, tout en contrôlant le score de gravité des blessures, l'âge, la pression artérielle systolique et l'utilisation d'anticoagulants. Une valeur P < 0.05 a été considérée comme statistiquement significative. Une analyse de sensibilité a également été utilisée pour valider les résultats primaires. RéSULTATS: Sur les 1013 activations d'équipes de traumatologie survenues pendant la période de l'étude, 762 patients ont été inclus. L'âge moyen (41.3 contre 43.8) et le pourcentage d'hommes (79.4% contre 77.5%) pour les activations préhospitalières étaient similaires à ceux de leurs homologues. Les activations préhospitalières n'ont pas eu d'effet statistiquement significatif sur la mortalité à 24 heures (14.4% contre 4.5%; P = 0.30). Cependant, les activations préhospitalières ont démontré une réduction statistiquement significative du temps (minutes) nécessaire à la procédure d'urgence (18.0 contre 27.0; P < 0.001), à la tomodensitométrie (37.0 contre 42.0; P = 0.009) et à la transfusion sanguine (14.0 contre 0.009). 28.0; P < 0.001), ainsi que la durée du séjour aux urgences (101.0 contre 171.0; P < 0.001). CONCLUSION: En tenant compte des principales covariables, l'activation de l'équipe de traumatologie préhospitalière n'a pas eu d'effet significatif sur la mortalité à 24 heures, mais a entraîné une réduction significative du temps nécessaire à l'intervention d'urgence, à la tomodensitométrie et à la transfusion sanguine, ainsi que de la durée de séjour dans les services d'urgence.

Increased Mortality and Costs Associated with Adverse Events in Intensive Care Unit Patients.

Background: Adverse events (AEs) are defined as unintended complications occurring to patients as a result of medical care. AEs are especially prevalent in the intensive care unit (ICU) setting and may lead to negative patient outcomes. Although many studies have examined the impact of AEs on patient outcomes, few have investigated their associated costs. Methods: The study population consisted of 17 173 adult patients (≥18 years of age) who were admitted to the ICU at The Ottawa Hospital (TOH) between 2011 and 2016. AEs were categorized using an established International Classification of Diseases 10th revision (ICD-10) patient safety indicators (PSI) system for AE detection. Logistic regression was performed to determine the association between AEs and in-hospital outcomes, including mortality. In addition, we constructed a generalized linear model to assess the independent association between AEs and total hospital costs. Results: Patients who experienced an AE had longer total hospital and ICU lengths of stay, required more invasive ICU interventions, had more complex discharge plans, and experienced higher rates of in-hospital mortality compared to those who did not experience an AE. Average total hospital costs and ICU-specific costs were higher among patients who experienced an AE ($72 718; $46 715) relative to their counterparts ($20 543; $16 217), but the per day cost was comparable in both groups. After controlling for age, sex, patient comorbidities, and illness severity, AEs were significantly associated with an increased odds of mortality (OR = 1.13, 95% CIs = 1.04, 1.22) and total average costs (Cost Ratio = 1.04, 95% CIs = 1.06, 1.08). The most impactful AE subtypes from a cost- and patient-perspective were hospital-acquired infections (HAI) and cardiac-related AEs. Conclusion: Incidence of AEs among ICU patients is associated with higher patient mortality and elevated costs. Specific causes of these AEs should be investigated, with further protocols and interventions developed to reduce their occurrence.

Extensive Upper Airway Hematoma Secondary to Supratherapeutic Warfarin Anticoagulation.

CASE PRESENTATION: A 63-year-old female presented to the emergency department complaining of cough, neck swelling, dysphagia, and dysphonia for two days, with a past medical history of atrial fibrillation managed with warfarin. Investigations revealed a supratherapeutic international normalised ratio (greater than 10). Imaging and endoscopic examination showed an extensive retropharyngeal hematoma with significant mass effect on the airway. DISCUSSION: A rare but potentially fatal complication of warfarin anticoagulation is upper airway hematoma, with violent coughing described as an inciting cause. Signs of airway compromise necessitate specialist consultation and definitive airway management, while mild cases without airway concerns can be managed conservatively with medical anticoagulation reversal.

The Different Facets of Dyslipidemia and Hypertension in Atherosclerosis.

Atherosclerosis is the narrowing of arteries due to the accumulation of macrophages overloaded with lipids resulting in foam cell formation, and these events occur preferentially at the branching points of arteries which are particularly susceptible to hyperlipidemic stress-induced inflammation and oxidative stress. The different stages of atherogenesis rely on oxidative stress, endothelial dysfunction, and inflammation, and hypertension or dyslipidemia can independently trigger these stages. Dyslipidemia and hypertension are pathological conditions that damage the endothelium, triggering cell proliferation, vascular remodeling, apoptosis, and increased cellular permeability with increased adhesion molecules that bind monocytes and T lymphocytes to create a vicious cocktail of pathophysiological factors. Correspondingly, the factors are redirected by chemo-attractants and pro-inflammatory cytokines into the intima of the vasculature, where monocytes differentiate into macrophages taking up oxidized LDL uncontrollably to form foam cells and atherosclerotic lesions. Moreover, endothelial damage also causes loss of vasomotor activity, disproportionate vascular contractility, and elevation of blood pressure in dyslipidemic patients, while in hypertensive patients, further elevation of blood pressure occurs, creating a self-perpetuating vicious cycle that aggravates the development and progression of atherosclerotic lesions. This review offers an in-depth analysis of atherosclerosis and the related interplay between dyslipidemia/hypertension and critically appraises the current diagnosis, etiology, and therapeutic options.