ABSTRACT
A case of cutaneous malakoplakia in an 81-year-old woman in reported. A reddish slowly growing plaque had appeared on her forehead 13 years previously. Histopathology revealed a dense dermal granulomatous infiltrate consisting of lymphocytes and numerous histiocytes containing Michaelis-Gutmann bodies. Ciprofloxacin treatment resulted in partial involution of the lesion.
Subject(s)
Facial Dermatoses/pathology , Malacoplakia/pathology , Aged , Aged, 80 and over , Anti-Infective Agents/therapeutic use , Ciprofloxacin/therapeutic use , Facial Dermatoses/diagnosis , Facial Dermatoses/drug therapy , Female , Forehead , Humans , Malacoplakia/diagnosis , Malacoplakia/drug therapyABSTRACT
We report a patient with multiple sclerosis who was receiving subcutaneous injections of recombinant interferon beta. During the third month of treatment, painful necrotizing cutaneous lesions appeared at the injection sites. The possible pathogenesis of interferon-induced skin necrosis is discussed.
Subject(s)
Adjuvants, Immunologic/adverse effects , Interferon-beta/adverse effects , Multiple Sclerosis/therapy , Skin/pathology , Adjuvants, Immunologic/administration & dosage , Adult , Erythema/etiology , Female , Humans , Injections, Subcutaneous , Interferon-beta/administration & dosage , Necrosis , Recombinant ProteinsABSTRACT
The case of an 81-year-old man with relapsing linear acantholytic dermatosis is described. This is the second description of this disease entity, which is characterized by the histopathologic and ultrastructural features of Hailey-Hailey disease. Clinically, it is characterized by skin lesions that wax and wane in a systematic pattern following the lines of Blaschko.
Subject(s)
Acantholysis/diagnosis , Abdomen , Acantholysis/drug therapy , Acitretin/therapeutic use , Aged , Aged, 80 and over , Biopsy , Epidermis/pathology , Groin , Humans , Keratolytic Agents/therapeutic use , Male , Recurrence , Skin/pathology , ThoraxABSTRACT
A total of 359 sera of untreated patients with syphilis were examined by three methods for the detection of Treponema pallidum specific IgM antibodies, the 19S-IgM-FTA-ABS test, the IgM solid phase haemadsorption assay (IgM-SPHA), and the IgM Captia assay. The results were compared and evaluated. In primary syphilis, the 19S-IgM-FTA-ABS and IgM-captia yielded reactive results in all patients, whereas only 40% were positive in the IgM-SPHA; the corresponding values for early latent syphilis wee 96.0%, 89.8% and 73.1%, respectively. In secondary syphilis, the reactivity of one serum out of 27 was missed by IgM captia and that of another, by the IgM-SPHA. Mean values (ELISA units = extinction/cut-off) of IgM-captia were higher in primary (2.25) than in secondary syphilis (1.70). In neurosyphilis, only the IgM-SPHA test detected reactivity in all sera, sensitivity for 19S-IgM FTA-ABS and IgM-Captia was 50.0% and 23.1%, respectively. Specificity of the IgM-Captia test results, determined in 386 sera, was 91.2%. The results of specific IgM tests are essential in the diagnosis of congenital syphilis as well as in the recognition of reinfection; they indicate the need for treatment and are useful in the assessment of the effectiveness of therapy.
Subject(s)
Antibody Specificity/immunology , Immunoglobulin M/blood , Syphilis Serodiagnosis/methods , Syphilis/diagnosis , Humans , Neurosyphilis/diagnosis , Neurosyphilis/immunology , Recurrence , Syphilis/immunology , Syphilis, Congenital/diagnosis , Syphilis, Congenital/immunology , Syphilis, Cutaneous/diagnosis , Syphilis, Cutaneous/immunology , Syphilis, Latent/diagnosis , Syphilis, Latent/immunology , Treponema pallidum/immunologyABSTRACT
Dyshydrosiform bullous pemphigoid is a clinical variant of bullous pemphigoid in which the lesions appear primarily on palms and soles. Knowledge of this unusual manifestation of bullous pemphigoid may be of practical relevance, since it has to be included in the differential diagnosis of blistering palmoplantar dermatoses. The correct diagnosis is confirmed by histological examination and immunofluorescence, which reveal all the characteristic hallmarks of bullous pemphigoid. Three patients with dyshydrosiform bullous pemphigoid are presented; clinical and histological aspects, findings on immunofluorescence, differential diagnosis and therapy are discussed.
Subject(s)
Eczema, Dyshidrotic/pathology , Foot Dermatoses/pathology , Hand Dermatoses/pathology , Pemphigoid, Bullous/pathology , Aged , Aged, 80 and over , Basement Membrane/pathology , Complement C3/analysis , Eczema, Dyshidrotic/drug therapy , Eosinophils/pathology , Female , Fluorescent Antibody Technique , Foot Dermatoses/drug therapy , Hand Dermatoses/drug therapy , Humans , Immunoglobulin G/analysis , Immunosuppressive Agents/therapeutic use , Male , Pemphigoid, Bullous/drug therapy , Skin/pathologyABSTRACT
The cause of recurrent pelvic and leg venous thromboses in a 24-year-old man was found to be a combination of two rare anomalies, hypoplasia of the hepatic, prerenal segment of the inferior vena cava and factor XII deficiency (factor XII activity 38%, its antigen 39% of normal), the latter considered a risk factor for thromboembolism. Subsequent fibrinolysis was not successful. No thromboembolic phenomena occurred during the following 16 months of oral anticoagulation with phenprocoumon. When this treatment was discontinued at the patient's behest, there was a recurrence on the contralateral side. Anticoagulation was resumed and has continued now for 1 1/2 years without recurrence. The patient has been largely free of symptoms. Permanent anticoagulation thus seems unavoidable in this case.
Subject(s)
Factor XII Deficiency/complications , Thrombophlebitis/etiology , Vena Cava, Inferior/abnormalities , Adult , Diagnosis, Differential , Drug Therapy, Combination , Factor XII/analysis , Factor XII Deficiency/diagnosis , Factor XII Deficiency/drug therapy , Humans , Male , Radiography , Recurrence , Thrombolytic Therapy , Thrombophlebitis/diagnosis , Thrombophlebitis/drug therapy , Ultrasonography , Vena Cava, Inferior/diagnostic imagingABSTRACT
36 patients suffering from systemic lupus erythematosus (SLE) were subjected to various screening and confirmation tests for the presence of lupus anticoagulants (LA) which are a risk for thrombosis. In five out of the 36 patients (14%) lupus anticoagulants could be found. Five out of the 36 patients (14%) showed increased antiphospholipid antibody (APA) levels whereby only two of these patients were at the same time LA-positive. The specificity, sensitivity and effectiveness of various tests in respect of LA-demonstrability have been assessed and the results taken as the basis for proposal of a largely automated stepwise diagnostic procedure for LA-determination within the routine coagulation laboratory.
Subject(s)
Lupus Coagulation Inhibitor/analysis , Lupus Erythematosus, Systemic/diagnosis , Adult , Blood Coagulation Tests/economics , Cost-Benefit Analysis , Female , Humans , Lupus Erythematosus, Systemic/immunology , Male , Middle AgedABSTRACT
Ischemic venous thrombosis that led to necrosis of four toes developed in an 81-year-old man. Despite the extensive thrombosis, results of blood clotting tests showed an extremely low prothrombin time (20%). Plasma mixing studies demonstrated an inhibitor that may have features in common with the lupus anticoagulant. Lupus anticoagulant also simulates hemorrhagic diathesis in vitro, whereas in vivo it is associated with thrombosis and thromboembolism. In contrast to the lupus anticoagulant, the inhibitor found in this patient was active within the extrinsic clotting system. Systemic steroids led to rapid clinical resolution paralleled by normalization of the prothrombin time and disappearance of the inhibitor.
Subject(s)
Factor VII/antagonists & inhibitors , Immunoglobulin G/blood , Immunoglobulin kappa-Chains/blood , Ischemia/etiology , Thrombophlebitis/etiology , Toes/blood supply , Aged , Aged, 80 and over , Autoantibodies/blood , Humans , Male , Prothrombin Time , Thrombophlebitis/bloodABSTRACT
Administration of etretinate in a 29-year-old female patient suffering from severe pustular psoriasis caused a dramatic increase in liver enzymes. Liver biopsy revealed changes characteristic for drug-induced hepatitis. After normalization of liver parameters following withdrawal of etretinate, isotretinoin was administered during a severe pustular relapse. In contrast to etretinate, isotretinoin was well tolerated and resulted in a good therapeutic response. Thus, isotretinoin can be considered as an effective and safe therapeutic alternative for pustular psoriasis even after the occurrence of etretinate-induced hepatitis.
Subject(s)
Chemical and Drug Induced Liver Injury/etiology , Etretinate/adverse effects , Isotretinoin/therapeutic use , Psoriasis/drug therapy , Adult , Chemical and Drug Induced Liver Injury/diagnosis , Etretinate/therapeutic use , Female , Humans , Liver Function Tests , Psoriasis/pathologyABSTRACT
Elastofibroma dorsi is a rare, benign tumor in elderly persons that usually occurs in the subscapular region. It represents a degenerative pseudoneoplastic process that resembles a malignant neoplasm. We report a patient with an elastofibroma dorsi of unusual size that ulcerated. This is a rare if not unique finding in elastofibroma dorsi.
Subject(s)
Fibroma/pathology , Skin Neoplasms/pathology , Aged , Aged, 80 and over , Female , Humans , ShoulderABSTRACT
Plasmapheresis represents a new and powerful treatment for solar urticaria and has been performed in a couple of patients so far. Since therapeutic responses have been observed exclusively in cases exhibiting a pathogenetically important serum factor, plasmapheresis seems to work specifically by elimination of this photoallergen. It is easy to demonstrate a serum factor by in vitro irradiation of the patient's serum and subsequent autologous reinjection into the skin, inducing the generation of wheals. In contrast to transfer tests, this method does not bear the risk of HIV infection. In view of the extreme difficulty in administering conventional therapy for solar urticaria, the present encouraging results suggest that plasmapheresis should be considered in patients who show a serum factor.
Subject(s)
Blood Proteins/analysis , Photosensitivity Disorders/therapy , Plasmapheresis , Urticaria/therapy , Adult , Female , Humans , Patch Tests , Photosensitivity Disorders/blood , Urticaria/bloodSubject(s)
Khellin/therapeutic use , Transaminases/blood , Ultraviolet Therapy , Vitiligo/therapy , Female , Humans , Middle Aged , Vitiligo/enzymologyABSTRACT
Apocrine chromhidrosis is an extremely rare and impressive skin disorder. Primarily after emotional stress patients complain of coloured sweat secretion (black, green, blue or yellow). The deposition of lipofuscin in the apocrine glands may be the cause of this disease, the different colours of sweat being due to various oxidation stages of lipofuscin. We report two patients, one with blue and one with green axillae; the clinical features, histopathology, differential diagnosis, and pathogenesis of apocrine chromhidrosis are discussed.
Subject(s)
Apocrine Glands/pathology , Pigmentation Disorders/pathology , Sweat Gland Diseases/pathology , Sweat Glands/pathology , Sweating , Aged , Axilla/pathology , Biopsy , Female , Humans , Middle AgedABSTRACT
Systemic mastocytosis associated with urticaria pigmentosa seems to be strikingly more common than previously assumed. The diagnosis can be established by the investigation of bone marrow sections, whereas bone marrow smears are less reliable. Some mediators are produced by the enhanced number of mast cells; telemethyl imidazole acetic acid is the most suitable mediator to calculate the size of the mast cell pool. Investigations like this might offer an alternative to the examination of bone marrow sections in future.
Subject(s)
Urticaria Pigmentosa/pathology , Biopsy, Needle , Bone Marrow/pathology , Female , Humans , Mast Cells/pathology , Middle Aged , Prostaglandins/blood , Skin/pathologyABSTRACT
Sixty-four patients received systemic alpha-interferon (10 million units subcutaneously daily) and 63 received systemic acyclovir (5 mg/kg body weight intravenously thrice daily) in a randomized study of acute herpes zoster. Start of healing, complete healing, development of new skin lesions in the primarily affected and in other dermatomes, and degree and duration of pain were evaluated. Both drugs proved equally clinically efficient without statistically different findings between the two groups; herpes zoster neuralgia was not prevented by either interferon or acyclovir therapy. Minor clinical side effects occurred slightly more frequently during interferon treatment and included fever and nausea. Transient and moderate leukopenia was observed in nearly all patients in the interferon group.
Subject(s)
Acyclovir/therapeutic use , Herpes Zoster/drug therapy , Interferon Type I/therapeutic use , Acyclovir/adverse effects , Aged , Clinical Trials as Topic , Female , Fever/chemically induced , Humans , Interferon Type I/adverse effects , Leukopenia/chemically induced , Male , Middle Aged , Nausea/chemically induced , Random Allocation , Recombinant Proteins/therapeutic useABSTRACT
Hypereosinophilic dermatitis represents a clinically distinct disorder in the spectrum of eosinophilic dermatoses. Its major clinical symptoms include pruriginous papular skin eruptions associated with blood eosinophilia. Histological examination reveals a diffuse, dense infiltration with eosinophils. We discuss the clinical picture, differential diagnosis, and therapy in the light of two cases.
Subject(s)
Dermatitis/pathology , Eosinophilia/pathology , Aged , Eosinophils/pathology , Female , Humans , Skin/pathology , SyndromeABSTRACT
Electron beam therapy applied to a lymph node metastasis from a squamous cell carcinoma was followed by the development of histologically and immunologically typical bullous pemphigoid, the lesions being initially strictly confined to the irradiation area. This observation suggests that the bullous pemphigoid antigen may be altered or unmasked by electron beam radiotherapy, leading subsequently to the production of autoantibodies. The disease in this case effectively responded to the administration of tetracycline and niacinamide, a therapeutic regimen described recently.
Subject(s)
Pemphigoid, Bullous/etiology , Radiodermatitis/etiology , Skin Diseases, Vesiculobullous/etiology , Aged , Diagnosis, Differential , Humans , Lymecycline/therapeutic use , Lymphatic Metastasis/radiotherapy , Male , Niacinamide/therapeutic use , Pemphigoid, Bullous/drug therapy , Pemphigoid, Bullous/immunology , Radiodermatitis/drug therapy , Radiodermatitis/immunologyABSTRACT
A 53-year-old male patient who had suffered for several years from severe persistent light reaction possibly due to tribromsalan photosensitivity was treated with cyclosporin A after long-term low-dose administration of corticosteroids which had to be discontinued. PUVA therapy was impracticable due to the extraordinarily high UVA sensitivity. When cyclosporin A blood concentrations between 100 and 200 ng/ml were reached, the patient was nearly free from symptoms; the excellent clinical response was also documented by phototesting performed prior to and during therapy. Cyclosporin A may be a valuable therapeutic alternative to systemic corticosteroids for severe cases of persistent light reaction which cannot be controlled by photoprotective measures.