ABSTRACT
Gene regulatory networks (GRNs) are crucial in every process of life since they govern the majority of the molecular processes. Therefore, the task of assembling these networks is highly important. In particular, the so called model-free approaches have an advantage modeling the complexities of dynamic molecular networks, since most of the gene networks are hard to be mapped with accuracy by any other mathematical model. A highly abstract model-free approach, called rule-based approach, offers several advantages performing data-driven analysis; such as the requirement of the least amount of data. They also have an important ability to perform inferences: its simplicity allows the inference of large size models with a higher speed of analysis. However, regarding these techniques, the reconstruction of the relational structure of the network is partial, hence incomplete, for an effective biological analysis. This situation motivated us to explore the possibility of hybridizing with other approaches, such as biclustering techniques. This led to incorporate a biclustering tool that finds new relations between the nodes of the GRN. In this work we present a new software, called GeRNeT that integrates the algorithms of GRNCOP2 and BiHEA along a set of tools for interactive visualization, statistical analysis and ontological enrichment of the resulting GRNs. In this regard, results associated with Alzheimer disease datasets are presented that show the usefulness of integrating both bioinformatics tools.
Subject(s)
Algorithms , Computational Biology/methods , Gene Regulatory Networks/genetics , Software , Animals , Gene Expression Profiling/methods , Humans , Models, Genetic , Mutation , Oligonucleotide Array Sequence Analysis/methodsSubject(s)
Duodenal Neoplasms/complications , Duodenal Neoplasms/diagnostic imaging , Intestinal Obstruction/etiology , Jejunal Diseases/etiology , Jejunal Neoplasms/complications , Jejunal Neoplasms/diagnostic imaging , Lipoma/complications , Lipoma/diagnostic imaging , Tomography, X-Ray Computed/methods , Abdominal Pain/etiology , Aged , Diagnosis, Differential , Humans , MaleABSTRACT
Hydropic degeneration of a uterine leiomyoma is common. Giant forms are uncommon. Positive diagnosis may be challenging because the differential diagnosis includes other rare uterine tumors such as leiomyosarcoma. Uterine localization, the leiomyoma volume, margins with adjacent structures are best evaluated at MRI. Final diagnosis requires gross and microscopic examination. We describe such a diagnostic challenge in a 46-year-old woman with a giant hydropic leiomyoma.
Subject(s)
Leiomyoma/pathology , Uterine Neoplasms/pathology , Female , Humans , Middle AgedABSTRACT
We report an uncommon presentation of plasmocytoma in an AIDS patient. AIDS is associated with an increased risk of neoplasms. The incidence of Plasma Cell tumors in HIV-positive patients is greater than in non-infected patients. Multiple factors contribute to B cell neoplasms development.
Subject(s)
Acquired Immunodeficiency Syndrome/complications , Duodenal Neoplasms/complications , Plasmacytoma/complications , Adult , Humans , MaleABSTRACT
Three cases of extraosseous Ewing sarcoma are reported. This pathology of the young adult is very rare as shown by the review of the literature. Clinical or imaging (CT or MRI) findings are non-specific and diagnosis is based on histology. Nonetheless, this diagnosis should be considered in all patients with primary soft tissue tumors.
Subject(s)
Muscle Neoplasms/diagnosis , Peripheral Nervous System Neoplasms/diagnosis , Sarcoma, Ewing/diagnosis , Spinal Nerve Roots/pathology , Adolescent , Adult , Diagnosis, Differential , Female , Humans , Male , Meningeal Neoplasms/secondary , Muscle, Skeletal/pathology , Neurilemmoma/diagnosis , Psoas Muscles/pathology , Sarcoma, Ewing/secondary , Thigh/pathologyABSTRACT
We present a case of symptomatic pneumatocyst of the ilium observed in a professional scuba diver exposed to pressure variations. Pneumatocysts are rare and except for one case reported in a clavicular localization, are always found in subchondral bone of the iliac or sacral side of the sacroiliac joint. Undoubtedly, air fills an intraosseous node. We report here the first case of efficient treatment achieved by filling the cyst via percutaneous access under scopic control.
Subject(s)
Barotrauma/diagnostic imaging , Bone Cysts/diagnostic imaging , Diving/injuries , Ilium/diagnostic imaging , Adult , Air , Barotrauma/therapy , Bone Cysts/therapy , Contrast Media , Embolization, Therapeutic , Humans , Ilium/injuries , Injections, Intralesional , Male , Polyvinyls/therapeutic use , Radiography, Interventional , Tomography, X-Ray ComputedABSTRACT
Se presentan 6 casos de colitis isquemica primaria. Los autores coinciden con la bibliografia consultada en cuanto a las localizaciones encontradas que fueron predominantemente en el colon izquierdo. Describen las fistulas y abscesos en 3 casos de formas estenoticas, que generalmente se atribuyen como patognomonicas de la enfermedad de Crohn y que constituyen una complicacion evolutiva de la colitis isquemica estenotica, pudiendo adoptar una forma pseudotumoral. En el diagnostico el colon por enema de doble contraste fue el aliado que figuro en todos los casos y la endoscopia solo corroboro la sospecha en 4 de ellos. Se efectuaron correlaciones entre la macroscopia observada y la radiologia, concluyendo que es muy dificil la diferenciacion radiologica entre el Crohn y la colitis isquemica en la forma estenotica complicada con fistulas y abscesos secundarios, casos en los que solo el estudio anatomopatologico puede lograr el diagnostico real
Subject(s)
Middle Aged , Humans , Male , Female , Colitis , Colonoscopy , IschemiaABSTRACT
Se presentan 6 casos de colitis isquemica primaria. Los autores coinciden con la bibliografia consultada en cuanto a las localizaciones encontradas que fueron predominantemente en el colon izquierdo. Describen las fistulas y abscesos en 3 casos de formas estenoticas, que generalmente se atribuyen como patognomonicas de la enfermedad de Crohn y que constituyen una complicacion evolutiva de la colitis isquemica estenotica, pudiendo adoptar una forma pseudotumoral. En el diagnostico el colon por enema de doble contraste fue el aliado que figuro en todos los casos y la endoscopia solo corroboro la sospecha en 4 de ellos. Se efectuaron correlaciones entre la macroscopia observada y la radiologia, concluyendo que es muy dificil la diferenciacion radiologica entre el Crohn y la colitis isquemica en la forma estenotica complicada con fistulas y abscesos secundarios, casos en los que solo el estudio anatomopatologico puede lograr el diagnostico real
Subject(s)
Middle Aged , Aged , Humans , Male , Female , Colitis , Colonoscopy , IschemiaABSTRACT
The authors have studied the veinous pattern of 30 livers of human foetuses from 190 to 390 mm V.C. The injection-corrosion method was used. The portal and sus-hepatic distribution is more frequently modal than for the adult. The portal anomalies touch more frequently the left branches: drainage of the right para-medial area by the left para-medial vein, agenesis or atrophy of the left segmentary branches. The right branch breaks up into several branches in 51% of the cases. The sus-hepatic anomalies are distinguished by the plurality of the veins. The right middle and inferior veins are present in 70% of the cases. Exceptionally large peripheral anastomoses between portal and sus-hepatic systems are observed.
Subject(s)
Liver/embryology , Fetus/anatomy & histology , Humans , Liver/blood supply , Portal Vein/embryology , Veins/embryologyABSTRACT
On two personal cases of left diaphragmatic congenital hernia, the authors study the innervation of the diaphragm. They describe a lower number of fibres in the phrenic nerve on the side of the malformation and don't find any branches coming from the intercostal nerves. This malformation is probably of neurogenic origin.
