ABSTRACT
BACKGROUND: Extra-digestive manifestations of Clostridium difficile infection are very uncommon. Exceptional cases of C. difficile bacteremia or severe sepsis have been described in intensive care patients, demonstrating the capacity of this agent to generate generalized infection. CASE REPORT: C. difficile bacteremia occurred in a 66-year-old immunodepressed patient treated for acute myeloblastic leukemia. Bacteremia was associated with a abscess of the anal margin. Outcome was favorable after treatment with metronidosole. DISCUSSION: Clostridium difficile is generally selected by prior antibiotic treatment. It is the principal agent of nosocomial diarrhea. In immunodepressed patients, systemic dissemination is a rare but possible development.
Subject(s)
Bacteremia/etiology , Clostridioides difficile/pathogenicity , Enterocolitis, Pseudomembranous/complications , Aged , Anti-Bacterial Agents/therapeutic use , Antineoplastic Agents/therapeutic use , Bacteremia/pathology , Humans , Immunocompromised Host , Leukemia, Myeloid, Acute , Male , Metronidazole/therapeutic useABSTRACT
BACKGROUND: Mycobacterium szulgai is an uncommon atypical mycobacterium human pathogen. CASE REPORT: The clinical manifestations and radiographic findings in a 31-year-old woman were strongly suggestive of pulmonary tuberculosis. The mode of transmission could not be determined. Mycobacterium szulgai was identified. The patient was treated with antituberculosis antibiotics and the clinical course was favorable. DISCUSSION: Mycobacterium szulgai is an atypical mycobacterrium difficult to identify. Its epidemiological features are unknown. This potential pulmonary pathogen is rarely described in the literature. Most cases have involved pulmonary, bone and joint or skin infections in immunodepressed patients. M. szulgai is relatively susceptible to classic antituberculosis antibiotics although standard regimens have not been established. Our patient required intensive care for mechanical ventilation.
