ABSTRACT
Augmentin suspension (amoxycillin+clavulanic acid) was estimated in clinico-laboratory studies with respect to children suffering from pyoinflammatory diseases of various localization and its high efficacy was shown. Good and satisfactory results were recorded in 96.3 per cent of the cases in the treatment (monotherapy) and afterwards in the patients, adverse reactions such as nausea and vomiting being recorded only in 1 patient. The therapy with augmentin led to normalization of the microflora of the upper respiratory tract mucosa and a 1.5-fold increase in the neutrophil engulfment index.
Subject(s)
Amoxicillin/administration & dosage , Bacterial Infections/drug therapy , Clavulanic Acids/administration & dosage , Focal Infection/drug therapy , Opportunistic Infections/drug therapy , Amoxicillin/pharmacology , Amoxicillin-Potassium Clavulanate Combination , Bacteria/drug effects , Bacteria/isolation & purification , Bacterial Infections/immunology , Bacterial Infections/microbiology , Child , Child, Preschool , Clavulanic Acids/pharmacology , Drug Therapy, Combination/administration & dosage , Drug Therapy, Combination/pharmacology , Drug Tolerance , Focal Infection/immunology , Focal Infection/microbiology , Humans , Infant , Infant, Newborn , Microbial Sensitivity Tests , Opportunistic Infections/immunology , Opportunistic Infections/microbiology , SuspensionsABSTRACT
Efficacy of doxycycline hydrochloride administered intravenously was studied in treatment of severe purulent inflammatory diseases such as pneumonia, lung abscesses, pyothorax, skin and soft tissue infections, peritonitis, purulent cholangitis, etc.. Doxycycline showed significant advantages over tetracyclines: prolonged action, higher efficacy and good tolerance. Favourable results were observed in 85 per cent of the cases.
Subject(s)
Bacterial Infections/drug therapy , Cholecystitis/drug therapy , Doxycycline/administration & dosage , Peritonitis/drug therapy , Respiratory Tract Infections/drug therapy , Skin Diseases, Infectious/drug therapy , Adolescent , Adult , Child , Humans , Infusions, Intravenous , Tetracycline/administration & dosageSubject(s)
Empyema, Pleural/drug therapy , Enterobacteriaceae Infections/drug therapy , Enterobacteriaceae/drug effects , Piperacillin/therapeutic use , Pleurisy/drug therapy , Pneumonia, Staphylococcal/drug therapy , Pseudomonas Infections/drug therapy , Pseudomonas/drug effects , Staphylococcus aureus/drug effects , Culture Media , Drug Resistance, Microbial , Empyema, Pleural/microbiology , Enterobacteriaceae Infections/microbiology , Humans , In Vitro Techniques , Microbial Sensitivity Tests , Piperacillin/pharmacology , Pleurisy/microbiology , Pneumonia, Staphylococcal/microbiology , Pseudomonas Infections/microbiologyABSTRACT
Comparative antibacterial activity of two novel ureidopenicillins (azlocillin and piperacillin), carbenicillin and ampicillin against 170 clinical strains of Enterobacteriaceae and 43 strains of Pseudomonadaceae was studied. Higher antibacterial activity of azlocillin and piperacillin evident from lower frequency of resistant strains and lower MICs for the majority of the isolates was shown. Impact of the inoculum size on the MIC values was observed with respect to all the penicillins. The study on the kinetics of Pseudomonadaceae death under the effect of azlocillin and carbenicillin revealed an increase in the bacteria growth after 6- to 8-hour contact with therapeutic concentrations of azlocillin and 4-hour contact with carbenicillin. Nor renewal of the culture growth was observed within 10-hour contact with combinations of the penicillins and 2 micrograms/ml of gentamicin.