Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Hepatomegaly/diagnosis , Liver Neoplasms/diagnosis , Liver/pathology , Lymphoma, Large B-Cell, Diffuse/diagnosis , Adult , Biopsy , Bone Marrow/pathology , Cyclophosphamide/therapeutic use , Doxorubicin/therapeutic use , Hepatomegaly/drug therapy , Hepatomegaly/etiology , Humans , Liver/diagnostic imaging , Liver Neoplasms/complications , Liver Neoplasms/drug therapy , Liver Neoplasms/pathology , Lymphoma, Large B-Cell, Diffuse/complications , Lymphoma, Large B-Cell, Diffuse/drug therapy , Lymphoma, Large B-Cell, Diffuse/pathology , Male , Prednisone/therapeutic use , Rituximab/therapeutic use , Tomography, X-Ray Computed , Treatment Outcome , Tumor Burden , Vincristine/therapeutic useABSTRACT
Haemophilia is a common cause of genetically inherited bleeding disorders. Pseudotumours occur in 1-2 % of persons with severe forms of haemophilia. These are a result of repeated haemorrhage into soft tissues, subperiosteum or a site of bone fracture with inadequate resorption of the extravasated blood. There are a number of therapeutic alternatives for this dangerous condition: surgical removal, percutaneous management, irradiation, embolization etc. In this case report, we describe the natural history, clinical course and successful surgical management of a patient with haemophilia who presented with a massive pseudotumour. We also briefly review the relevant literature on the various therapeutic modalities that have been implemented in the management of this rare complication. Though surgeons may be averse to operate on haemophiliacs, primary surgical management as done in our case may prove to be the definitive treatment option for such patients.
