Design, Synthesis, Biological Evaluation and in Silico Studies of Curcumin Pyrrole Conjugates.

Curcumin conjugated heterocyclic compounds are potent candidates with drug likeness against various bacterial pathogens. A set of curcumin-based pyrrole conjugates (CPs) were synthesized and characterized by FT-IR, 1H and 13C NMR and HR-MS techniques. The results of free radical scavenging activity of the synthesized CPs, evaluated by FRAP and CUPRAC assays, showed the potency of these compounds as effective antioxidants. CP3 exhibits the highest antioxidant activity amongst the CPs. The bactericidal efficacy of CPs was screened against ESKAP bacterial pathogens, and CPs were found to possess better antibacterial property than curcumin, specifically against staphylococcus aureus bacteria. In addition, serum albumin (BSA and HSA) binding interaction of these CPs were determined by UV-visible and fluorescence spectrophotometric techniques. In-silico molecular docking study was performed to determine the binding patterns of molecular targets against Staphylococcus aureus tyrosyl tRNA synthetase, and serum albumin proteins. The structure-activity relationship showed that the presence of multiple phenolic hydroxyl groups, and electron withdrawing groups on the structure of CP molecule, enhances its antioxidant and antibacterial activity, respectively.

Blockchain technology in supply chain operations: Applications, challenges and research opportunities.

Blockchain is a technology with unique combination of features such as decentralized structure, distributed notes and storage mechanism, consensus algorithm, smart contracting, and asymmetric encryption to ensure network security, transparency and visibility. Blockchain has immense potential to transform supply chain (SC) functions, from SC provenance, business process reengineering to security enhancement. More and more studies exploring the use of blockchain in SCs have appeared in recent years. In this paper, we consider a total of 178 articles and examine all the relevant research done in the field associated with the use of blockchain integration in SC operations. We highlight the corresponding opportunities, possible societal impacts, current state-of-the-art technologies along with major trends and challenges. We examine several industrial sectors such as shipping, manufacturing, automotive, aviation, finance, technology, energy, healthcare, agriculture and food, e-commerce, and education among others that can be successfully revamped with blockchain based technologies through enhanced visibility and business process management. A future research agenda is established which lays the solid foundation for further studies on this important emerging research area.