PCy3-assisted Ag(I)-catalyzed click reaction for regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles at room temperature.

An approach towards Cu-free click chemistry has been developed in this work. Silver-catalyzed PCy3-ligand-assisted synthesis of 1,4-disubstituted 1,2,3-triazoles at room temperature has been developed. Regioselectivity of the reaction was confirmed from the results of single-crystal X-ray diffraction (SC-XRD) of one of the products. SC-XRD of ex situ-generated Ag-PCy3 complex helped us propose a plausible mechanism for the reaction. This reaction was indicated to exhibit a catalytic activity level similar to that for the in situ-generated complex. The methodology was found to work well with benzyl azides, phenyl azides, terminal alkynes and internal alkynes in aqueous medium. The one-pot three-component reaction leading to 1,2,3-triazole synthesis also proceeded well.

A Review of Partial Information Decomposition in Algorithmic Fairness and Explainability.

Partial Information Decomposition (PID) is a body of work within information theory that allows one to quantify the information that several random variables provide about another random variable, either individually (unique information), redundantly (shared information), or only jointly (synergistic information). This review article aims to provide a survey of some recent and emerging applications of partial information decomposition in algorithmic fairness and explainability, which are of immense importance given the growing use of machine learning in high-stakes applications. For instance, PID, in conjunction with causality, has enabled the disentanglement of the non-exempt disparity which is the part of the overall disparity that is not due to critical job necessities. Similarly, in federated learning, PID has enabled the quantification of tradeoffs between local and global disparities. We introduce a taxonomy that highlights the role of PID in algorithmic fairness and explainability in three main avenues: (i) Quantifying the legally non-exempt disparity for auditing or training; (ii) Explaining contributions of various features or data points; and (iii) Formalizing tradeoffs among different disparities in federated learning. Lastly, we also review techniques for the estimation of PID measures, as well as discuss some challenges and future directions.

Production and characterization of an alkaline thermostable crude lipase from an isolated strain of Bacillus cereus C(7).

A bacterial strain isolated from spoiled coconut and identified as Bacillus cereus was found capable of producing alkaline thermostable extracellular lipase. Optimum temperature, time, and pH for enzyme substrate reaction were found to be 60 degrees C, 10 min, and 8.0 respectively. Common surfactants except Triton X 100 and cetyltrimethylammonium bromide have no or very little inhibitory effects on enzyme activity. The enzyme was found to be stable in presence of oxidizing agents and protease enzyme. The maximum lipase production was achieved at 30-33 degrees C, pH 8.0 on 24 h of fermentation using 50 ml medium in a 250-ml Erlenmeyer flask. The superior carbon and nitrogen sources for lipase production were starch (2%) and ammonium sulfate (nitrogen level 21.2 mg/100 ml), peptone (nitrogen level 297 mg/100 ml), and urea (nitrogen level 46.62 mg/100 ml) in combination, respectively. The maximum enzyme activity obtained was 33 +/- 0.567 IU/ml.