ABSTRACT
PURPOSE: To analyze the spectrum of aggressive posterior retinopathy of prematurity and outcome after laser treatment. METHODS: This is a retrospective review of 81 eyes of 44 consecutive infants diagnosed to have aggressive posterior retinopathy of prematurity and treated between September 2005 and March 2007 from a large tertiary care center in North India. Qualitative variables were tested for statistical significance using the chi-square test and independent samples with the student's t-test. RESULTS: Mean birth weight and gestational age were 1,259.66 +/- 310.51 g (range, 660-2,000 g) and 29.75 +/- 2.35 weeks (range, 26-36 weeks), respectively. Twenty-one infants (47.72%) had a birth weight > 1,250 g. Thirty-three (40.74%) eyes had Zone 1, and 48 (59.26%) had posterior Zone 2 disease. All eyes underwent confluent laser photocoagulation at a mean postconceptional age of 34.58 +/- 2.19 weeks (range, 31-40.5 weeks). Mean follow-up was 12.8 months (range, 6-24 months). At the last follow-up visit, 55 (71.4%) of 77 eyes had a favorable outcome. Eighteen eyes (23.4%) had a localized (1-3 clock hours) partial peripheral tractional detachment (Stage 4a), which remained stable at last follow-up. Two eyes (2.6%) developed falciform fold involving the macular area, and 2 (2.6%) developed Stage 5 retinopathy of prematurity. CONCLUSION: Aggressive posterior retinopathy of prematurity is encountered not only in low birth weight infants, but also in heavier and more mature Asian Indian infants. Early, aggressive confluent laser photocoagulation is necessary to maximize outcomes in these eyes.
Subject(s)
Laser Coagulation , Retinopathy of Prematurity/complications , Retinopathy of Prematurity/surgery , Asian People/ethnology , Birth Weight , Follow-Up Studies , Gestational Age , Humans , India/epidemiology , Infant, Newborn , Lasers, Semiconductor/therapeutic use , Retinopathy of Prematurity/ethnology , Retrospective Studies , Treatment OutcomeABSTRACT
PURPOSE: To study the structural sequelae and refractive outcome in eyes with a favorable structural outcome following laser treatment for threshold retinopathy of prematurity (ROP). METHODS: Premature infants with threshold ROP had laser treatment with a minimum follow-up of 1 year. Complete ocular examination and refraction was done. Analysis and correlation of structural sequelae and refractive outcome was done. RESULTS: One hundred eighty-four eyes of 93 preterm infants were followed up. Structural changes such as vascular tortuosity, narrowing of arcades, temporal crescent, disc drag, and macular heterotopia were seen. Mean refractive error observed was -4.71 D spherical equivalent. Myopia was seen in 80.43% of eyes. CONCLUSIONS: The study revealed various structural sequelae and their correlation with refractive outcome.
